Zytiga and Blood Pressure

[Twoofus]

If this has been posted before for discussion, I’m sorry for a redo. Hell I may have posted it before; can’t remember.

I’ve been on Zytiga for almost three months. It is working except for blood pressure. Over the past month it has gone from normal to very high (175/105 range).

So now I’m working with another doctor: my cardiologist. I have gone to him for 20 years. He discovered my blockages which led to my triple bypass. I trust him to do the correct thing.

Anyone else had this problem? How was it brought back toward your normal? Any other information is welcome. Thank you.

[Grumpyswife]

Yours sounds more serious then my husband's hypertension. His has gone down since starting Zytiga. He has always had white coat syndrome but normal readings at the CVS machine.

He's used Losartan Potassium with Hydroclorazide 100mg/12.5mg (half a tab) for at least 10 years. Due to his thyroid issues last year they added 25 mg Atenolol which seems to be doing an amazing job. He is routinely 120-125/80 in the office.

Not sure if that helps you, though.

[tango65]

If you are taking 10 mg of prednisone a day along with the zytiga, discuss adding eplerenone to control your hypertension. Hypertension when taking zytiga may occur because there is an increase in aldosterone. Aldosterone will cause sodium retention and hypertension associated or not with edema and hypokalemia. Eplerenone is an specific aldosterone receptor blocker.

If you are taking 5 mg of prednisone, then increasing the prednisone to 10 mg could help to control the blood pressure.

[LearnAll]

Zytiga has worsened my high blood pressure so now I am on 3 BP drugs to control it namely Losartan, Amlodipine and atenolol. I stopped Zytiga for a few days to see if BP gets lower.

[tango65 in reply to LearnAll]

The pathophysiology of hypertension when taking zytiga is an increase in aldosterone. You could discuss to measure your aldosterone and if elevated you could discuss to have treatment with eplerenone or with spironolactone which are blockers of the aldosterone receptors. If you are taking 5 mg of prednisone you could discuss increasing the dose to 10 mg.

[Tall_Allen]

You may not be getting enough prednisone. Discuss increasing it while you monitor BP.

[EdBar]

Yes had BP, issues but with Xtandi instead of Zytiga, I’m working with my cardiologist as well to try and find the right mix of BP meds that won’t interfere with the effectiveness of my ADT meds and won’t add to fatigue. As my cardiologist put it - “you’ve got enough poison running around inside you”.

Ed

[tallguy2]

I started Zytiga 5 weeks ago. My BP had always been "normal" before then. It has been ranging high since starting Zytiga plus Erleada.

Tomorrow I start amlodipine, a low-dose blood pressure medicine.