Note that Lovastatin did very poorly, but not many men were using it. Simvastatin, which had more users than the other statins combined, was disappointing. This is a concern for me, since previous studies were favorable & I have been using it for over a dozen years because of that. On the other hand, when I checked this morning, I was still alive.
Note for red yeast rice users: it contains the chemical patented as Lovastatin.
-Patrick
Written by
pjoshea13
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I have never doubted that there was incremental benefit - & with very little downside. The benefits don't occur overnight & men should not expect dramatic results. I do a lot of little things that might help & believe that the sum of the incremental benefits might just get me to 20 years.
No doubt some will crow if a negative study turns up next, but I'm content with the weight of available evidence.
Systemic bioavailability is low for simvastatin and lovastatin (I've been taking lovastatin because it has been the only one I've found that doesn't give me insomnia - rare side effect).
Interesting that Pravastatin performs so well. It is hydrophilic. In fact, according to this study the hydrophilic statins outperform the lipophilic statins. Any thoughts as to why that might be?
Incidentally, hydrophilic/lipophilic isn't exactly an either/or condition.
"The atomic electrostatic potentials calculated by the CHELPG method have been shown to be sensitive indicators of the gas phase and solution properties of the statins. Solvation free energies in water, n-octanol and n-octane have been determined using the SMD solvent model. The percentage hydrophilicity and hydrophobicity (or lipophilicity) of the statins in solution have been determined using (a) the differences in solvation free energies between n-octanol and n-octane as a measure of hydrophilicity, and the solvation energy in octane as a measure of hydrophobicity (b) the sum of the atomic electrostatic charges on the hydrogen bonding and polar bonding nuclei of the common pharmacophore combined with a solvent measure of hydrophobicity, and (c) using the buried surface areas after statin binding to HMGCR to calculate the hydrophobicity of the bound statins. The data suggests that clinical definitions of statins as either “hydrophilic” or “lipophilic” based on experimental partition coefficients are misleading."
"Atorvastatin users had an 82% decreased risk of PCa mortality compared with individuals who did not use statins. By comparison, use of lovastatin, pravastatin, rosuvastatin, and simvastatin was associated with a 55%, 18%, 67%, and 24% decreased risk, respectively."
I was on both metformin and pravastatin......for 10 yrs prior to dx of stg4 mpc...matbe it gave me pc....ive always been different....skewd the results...good luck
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Interesting study on combination of statins and metformin in high-risk patient outcomes
Effect of statins and thiazides on PSA
