Clinical trial S1802 (adding radiation or radical prostatectomy to standard treatment for cspc)?

[Barbara345]

Hi, Is anyone on the clinical trial S1802 where at 22 to 28 weeks after first treatment for metastatic pc, they compare "standard of care" alone with standard of care plus either radiation or radical prostatectomy? Husband's oncologist mentioned this trial for him to consider; many hospitals are enrolling. Husband has bone mets, Gleason 9, on Lupron and just finished 5h round of Docetaxel. Thanks all.

[GP24]

Radiation helped a lot in a large trial in England:

ascopost.com/News/59392

However, I would not take part in the trial but just try to get the radiation done and avoid to end up in the control group of the trial.

[Barbara345 in reply to GP24]

We've thought about that too....Barry definitely is more interested in the the radiation than the prostatectomy.... we'll be having ongoing discussions with the MO. First, chemo gets finished, and we have through part of March to decide.

[Tall_Allen]

How many bone metastases? If there are 3 or less, it may be beneficial:

pcnrv.blogspot.com/2018/09/...

It will be up to him and his doctor if he wants radiation or surgery. He can't have chemo or metastasis-directed therapy after randomization (although he can have it before).

clinicaltrials.gov/ct2/show...

[Barbara345 in reply to Tall_Allen]

There are multiple metastases. His MO said they can discuss this further when they evaluate him, if he wants to consider going forward with it.

[Tall_Allen in reply to Barbara345]

Even though it won't extend his life, it may prevent urinary problems down the road. The trade-off is that he will have some urinary problems now.