BET inhibitors may be next after all SOC treatments, AR drugs fail?

[JLS1]

Anyone here know anything about BET inhibitor drugs? Has anyone been in any of the clinical trials?

webmd.com/prostate-cancer/f...

"The move to use androgen receptor drugs earlier against prostate cancer means researchers are going to need to come up with new treatments when the prostate cancer becomes resistant to the AR drugs and they begin to fail, Fong says.

One possibility is bromodomain and extraterminal (BET) inhibitors. Cancers have BET proteins. In one study, BET inhibitors worked well against prostate cancer that had become resistant to the AR drug enzalutamide.

Researchers are looking beyond cancer drugs, too........"

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Transcriptional Reprogramming and Novel Therapeutic Approaches for Targeting Prostate Cancer Stem Cells

Review ARTICLE

Front. Oncol., 09 May 2019 | doi.org/10.3389/fonc.2019.0...

frontiersin.org/articles/10...

"Currently, several BET protein inhibitors (e.g., ZEN003694, OTX015/MK-8628, ABBV-075, INCB057643, GSK525762/I-BET762, GS-5829) are in phase I/II clinical trials, with some studies specifically assessing their efficacy in prostate cancer patients alone or in combination with AR-targeted therapies (112). In prostate cancer, BET protein inhibitors modulate AR signaling and enhance the anti-androgenic effect of AR-targeted therapies in AR positive prostate cancer cells such as VCaP and LNCaP cells, making them suitable drugs for treatment of mCRPCs (113–116). Interestingly, BET protein inhibitors interfere with Myc functions in preclinical cancer models (106, 108, 110) and, therefore, have the potential to inhibit Myc-dependent processes also in prostate CSCs."

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I wonder how this trial has been going:

urotoday.com/clinical-trial...

[tango65]

Talk with the people running these trials:

clinicaltrials.gov/ct2/resu...

[JLS1 in reply to tango65]

Thank you!!!