Thankyou Welcome

[Hotrod65]

5 yr survivor with MPC4 Gleason 9 (4+5) PSA 10.5 Aggressive NEPC Neuroendocrine carcinoma..Given 3-6 months at Diagnosis, No response to Conventional treatment to include RPT, HDT and 1.5 yrs of Chemotherapeutic drugs, Experimental Trial started after Genomic Sequencing done on Pathology. Tumor markers Negative, but Foundation Medicine CDx Panel indicated a Hypermutated HBM and started on Checkpoint Inhibitors immunotheraphy Pembrolizimab Keytruda...47 infusions with another year to go... currently in Complete Clinical Remission NED, living a pretty normal Quality of Life...God Bless all PC Warriors.

[tallguy2]

Excellent results given a difficult diagnosis! Blessings to you for continued health in 2020!

[AlanMeyer]

It's great that the Keytruda is working! That's a drug that was thought to not work for prostate cancer and it was only recently hypothesized that it would work for some kinds of patients. It looks like you're one of those kinds. You've had at least one piece of excellent luck in this process.

I hope it continues on and on.

Alan

[Hidden]

You rock Hotrod65, 75 was a good year. 3-6 months ? but you’ve put that notion to rest . A great job surviving with APC . Keep rockin🎸

[JLS1]

Wow, that is awesome!! - and SO encouraging for others who have been deeply discouraged by their MO's comments!! Prayers you continue to enjoy a 'normal' life with this treatment, or the next, until THE cure is finally found!!

I wonder if the Foundation Medicine CDx Panel is the same as the Guardiant 360 test that my husband recently had?

May I ask who your MO is - where you're getting tested and treated? TIA

[Hotrod65 in reply to JLS1]

I'm being treated in Boston, at Tufts Medical Cancer Center, my MO is Dr.Paul Mathew, a Nationally Ranked Geniturinary Oncologist with a Specialization in PC, He is also professor and Director of the Molecular Oncology Research Lab at Tufts.. I sought him out after Diagnosis over other prestigious Hospitals in Boston due to Tufts known ability to take on many new and differcult cancer cases...they are saving my life and certainly made the right decision.

[DarkEnergy in reply to Hotrod65]

Wonderful to hear about your treatment response. I did my research as well selecting my MO, Dr. Mark Pomerantz from Dana-Farber, he actually puts in time with patients and explains the current state of PCa treatments.

I'm one year in, diagnosed PSA 1000+, with large tumors extending from the prostate and extensive metastasis throughout the vertebrae. First doc, Oncologist from Lahey Health gave me less than a year. But, my cancer cells are very sensitive to ADT and PSA dived to <0.02 and holding.

Did you requested the FoundationOne CDx?

[Hotrod65 in reply to DarkEnergy]

No I didn't request Sequencing, in fact being Metastatic, the Prostate Gland is not typically removed, in my case they wanted it done, a decision that saved my life when they had the complete tumor to evaluate and matched my Mutational load to effective treatment with Checkpoint Inhibitors Blockade..I'm familiar with Dr.Pomerantz at DF, know other patients of his and I believe he attended a speech I gave at DF back in June this year as an Advocate for Cancer Research Institute for the Advancement of Immunotherapies., I also travel the Nation as an Advocate Speaker for Foundation Medicine, have several publications, Newspaper articles, Medical Editorials currently airing across the country on TV, I am the Poster Boy for MPC4 Immunotheraphy and confirmed to be possibly one in the world that has gotten a complete Clinical Remission from it...Have Hope and Inspiration from that. God Bless

[Hidden in reply to DarkEnergy]

Hold on PSA . !

[Tall_Allen]

Great to hear you found something that works for you. Here are some clinical trials you may want to investigate:

pcnrv.blogspot.com/2016/12/...

[Alicat1]

Apart from trying it is there any other way to see (blood tests etc) if one would make a good candidate for Keytruda?

[Hotrod65 in reply to Alicat1]

Genomic Sequencing of tumor pathology will identify the cancer Mutational load and match it to a targeted treatment or clinical trial..insist on having testing done..very expensive but now covered by those on Medicare after FDA approval.

[2dee]

Wow congratulations, after one year a five year goal might just be possible. We have your proof. Keep going and keep us informed.

2Dee

[Vindog29]

So wonderful to read, may you have continued good health. My husband only got 2 treatments of keytruda for his MSH2 mutation before his liver enzymes rose..I wonder what would have happened if he had more, perhaps remission too since with just 2 his PSA is undetectable. Thank GOD and research for Keytruda.

[pilot52]

Flying today.....cannot loop this one but will do something funky....Blue Skies , Sky King and Penny (woof)

[j-o-h-n]

Congrats....Good news and good work.... I used to have a Hot Rod..... too....Got me into trouble sometimes... but alas no worry since I have a Dead Rod now........

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 12/26/2019 6:12 PM EST

[Hotrod65 in reply to j-o-h-n]

Lol, yeah I have 2 Hot Rods, one I drive and the other is surely non functional these days..but we all know about that.

[monte1111 in reply to j-o-h-n]

Hope you found a double garage to park that in.

[j-o-h-n in reply to monte1111]

Unfortunately that garage is closed to inoperable former hot rods..........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/27/2019 4:57 PM EST

[jfoesq]

Awesome!!!

[dasyluo]

Good news, God blessed. It is inspiring.