ADT resistant pca

[Ayra1]

Dad is now ADT resistant. Can I see a hope for his survival. Seeking best treatment in India. Advice please.

Only on zoladex. Should tabi be added

[LearnAll]

ADT resistant does not mean treatment resistance. Its only treatment resistance to one type of treatment and that is androgen blockade,

If you provide details about your dad's situation, some one can show you the direction you need to go. This forum is full of some very smart and knowledgeable people.

[Magnus1964]

What ADT drugs has he been on? There are many others and each could provide years of quality life.

[Ayra1]

He is on zoladex only for almost 3 years. He had a solitary femur met. Was given sbrt and ADT.now his psa is rising rapidly with low testosterone. Last was . 06 which has increased from <.008 in almost 5 months. Worried about prognosis. Please suggest next steps

[Tall_Allen]

In the US, approved drugs for metastatic castration-resistant PC include docetaxel, abiraterone, enzalutamide, radium 223, sipuleucel, and cabazitaxel. In India, you can also get Lu-177-PSMA. If he only had the one met, radiation to his prostate may be helpful too.

[Ayra1]

What is the life expectancy of Adt resistant CA prostate. Also when shoul we start the next treatment and scans

[LearnAll]

There is no certain way to tell who will live how long..people with CRPC have lived anywhere from 5 to 15 years even....because we have so many new treatments

like Tall Allen said above...Abiraterone. Docetaxel, Enzalutamide, Radium223, Lu177.

And I know most of new treatments are available in India. including immunotherapy.

[Hidden]

Just want to point out that his PSA is .06. This is not considered castrate resistant by any standard I know of. He may continue for quite a while only requiring primary ADT. When his PSA gets above 2, then his doctors can begin to consider whether he is becoming castrate resistant. And of course as discussed, he has quite a few options at that point. PSA increases of tenths or hundreths are meaningless to metastatic prostate cancer patients.

[LearnAll]

Ayra1

Did you hear what Gregg just said...."your Dad is not ADT resistant yet". Touch Dad's feet, get his blessings and give this good news to him and entire family.

Like Gregg said as long as his PSA stays below 2 ,he will be considered Castration sensitive.

However, abiraterone still can be added to optimize outcome further. Put good amount of turmeric (haldi) , Ginger (adrak) and Garlic in his lentil soup(daal) and curry(Sabzi). Good luck to you and your Dad.

[tallguy2 in reply to LearnAll]

Agreed.

[Hidden in reply to LearnAll]

Bravo! 👏

[Hidden in reply to LearnAll]

I do all except Sabzi ? Is it really good tasting and or good for pc? 😎

[LearnAll in reply to Hidden]

Lulu,

Curry is a British word....for Hindi word "Sabzi" Sabzi is a general term for any vegetable which is cooked in Indian way. Lets take an example: Take a cauliflower, cut it into small pieces. Then, for the paste (masala) cut onions, garlic, red tomatoes , ginger..into very small pieces. Add salt per your liking. Add grounded turmeric , coriander powder,

Put one or two teaspoons of oil of your choice . Let the oil get heated. Then, throw some cumin seeds into oil. Once you see cumin seed turn brown, put all your paste (see above into the pot, stir it and pour a cup of water. Let the paste simmer in light heat until it becomes uniform and mixed looking like paste. Then cauliflower pieces are added and let this simmer in light heat until this stuff gets cooked well , In between, keep stirring every 2 minutes. Once ready, sabzi can be eaten along with bread. This is very basic way of making any veg curry. In place of cauliflower, Cabbage, broccoli, okra, potatoes any veg. can be used BUT the paste part remains the same. Sabzi is anti cancer food.

[j-o-h-n in reply to LearnAll]

Thanks for the info.... Now Umustay and Imustgo........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/20/2019 2:10 PM EST

[LearnAll in reply to j-o-h-n]

Umustay...Imustay….Allmustay…....No one Go...! Cheers ! John the Great !

[j-o-h-n in reply to LearnAll]

And don't forget Namaste..... Cheers back to he who learnedAll.....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/20/2019 5:21 PM EST

[RayF in reply to j-o-h-n]

Nah,imastay!

That was funny as hell John

[j-o-h-n in reply to RayF]

I thought so too.... But East Indians didn't get it............

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/20/2019 6:03 PM EST

[Hidden]

I agree with gregg57’ s sound thinking . Psa still super low .

[tallguy2 in reply to Hidden]

Agreed.

[Hidden in reply to tallguy2]

The Panick of not knowing is real . Fear of losing a father hard... For us that cloud of reoccurrence hanging overhead us never really stops .... Zen mode Is needed... to skip along without obsessing about pc.

[Hidden in reply to Hidden]

I learned one of the most important lessons in my doctor's office. I went through the treatments available with my doctor and after she told me about each one, I said "and what happens after that?" eventually we got to end of the list and after my final "and what happens after that?" she said "We'll have to get comfort care for you." I immediately broke down crying and thinking to myself "Oh my God, I'm going to end up in hospice!"

After I calmed down and left the appointment, I remember thinking to myself "What the hell did you just do?" I really felt stupid and never allowed myself do anything like that again.

IMO, we must stay disciplined about not living in the future, not trying to predict what terrible things are going to happen to us and not senslessly worry about things like our PSA. The time we have left here is too precious to waste, our quality of life too valuable to squander. Guard your quality of life and resist the temptation to wander into a future you can't predict.

[Hidden in reply to Hidden]

Amen brother.. perspective is everything ..but we admit initially the fear is real .. and tentative .. Merry Christmas

[Hidden in reply to Hidden]

Agree. The fear is tangible, but rising it above it and living fully inspite of it is an amazing and powerful experience. Fear is an opportunity to have courage.

[Hidden in reply to Hidden]

It’s easy for me to not have fear when I have no signs of pc right now . If or when APC comes to eat me up again . I’ll be crying like a baby then .. I feel for those in fear . It s the super bad bad of this deal . I’m not really brave just lucky I guess .. 🌵

[Hidden in reply to Hidden]

Yes, it's easier when things are going well. When things change for the worse there is always a relapse into grief and fear. For me, it takes me back to the trauma of that time in the doctor's office when I was given "the news". It's a struggle, but so far I've been able get back on my feet again.

No question about it, this whole thing is difficult. Trying to make the best of it is a real challenge, but there are rewards there too.

[Hidden in reply to Hidden]

Let’s put some lipstick on this pig and ride it til we can’t ride no more . ✌️

[tom67inMA in reply to Hidden]

That's me too! It's easy to be brave when undetectable and feeling good. A bit of fatigue and some new ache and the facade starts to crack.

[Hidden in reply to tom67inMA]

Last visit with my MO I was panicking about a lump on the side of my upper neck thinking it might be a cancerous lymph node. My doctor felt it and said, "That's not a lymph node, feels like a zit to me." I was almost surprised "What? I thought it would have to be some kind of tumor. You can actually have a zit with stage 4 Prostate Cancer?" I've become so "trigger happy" for lack of a better expression. Normal aches or pains can send me into depression or make me emotional. It's something we all have to live with. Not easy.

[tom67inMA in reply to Hidden]

Yep, and it's so unfair that we still have to deal with the common cold, acne, and other such routine ailments. That said, I do believe the prednisone has helped my exercise induced asthma.

[Hidden in reply to tom67inMA]

That’s looking at the bright side ! I too have some asthma . No prednisone so far ..the best present is an undetech status .. 🎊

[Hidden in reply to Hidden]

With The muscle and joint pain while being castrated if felt it could be Metz . Thank god for me it’s wasn’t.. If I had a lump on my neck I’d be a little freaky too .. I’m not really brave ,just lucky for some reason? Enjoy your Christmas !🎄😂

[Hidden in reply to tom67inMA]

When we feel APC ‘s teeth in us , then there is fear .. We must gives thanks that we’re not burning up at the moment....... peace Tom . 🎄

[Boywonder56 in reply to Hidden]

Spoke wisely man....merry christmas....or w.e.

[Manilo]

In my opinion

0.08 PSA is so low that it won't mean castrate resistant.

Mine moves around 0.04 to 0.08 up and down. Maybe won't go lower because I have a prostate (well at least half).

If your father has a prostate, any tiny inflamation will rise a bit his PSA.

I wouldn't panic.

Monitor that PSA. And do a Pet/TC if it rises. FDG & PSMA. But I doubt you can find any progression in images below 0.10.

[Ayra1]

Thank you so much everyone

[Hidden]

Dear Ayra1 , good feedback . No need to panick now . Hold him during these holidays and share love . We can’t sugar coat this disease. It s a brut .. take care and enjoy you day 😎

[j-o-h-n]

How old is your Dad? Treatments to date? PSA/Gleason scores? Thank you....

Now Umustay and Imustgo........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 12/20/2019 2:12 PM EST

[Ayra1]

He is 65. He has had RP. Then was kept on active surveillance. Had mets to femur. Received sbrt and zoladex for three years now. Psa now on a rising trend since 5 months. Gleason was 9. Latest psa of .06

[Hidden in reply to Ayra1]

Any rise in Psa grabs us by the short hairs . With this slight increase there is time to try something new ... Enjoy time with him . Deal with this after New Years. Please let me know what he’s given to bring it back down ? No gloom or doom he can deal with this . 🎄🎄

[Ayra1]

Is there any role of genetic mapping now. Blood/block or both? Will I be able to know n treat prostate cancer better?

[SsgCulldelight]

You're in India? Change diets that'll be the best.

[Ayra1 in reply to SsgCulldelight]

Suggestions for diet