My 16 year old daughter is now fighting a recurrence of GBM4 after proton radiation and Temozolomide failed to control it. We are about to start Fenbendazole and need appropriate dosing information. She weighs 172 pounds. Can anyone give me advice?
Fenbendazole for Glioblastoma IV - Advanced Prostate...
Fenbendazole for Glioblastoma IV
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Barrymart
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This is the advanced protate cancer forum so not sure you will get much help here. You can try this forum. It may be more helpful.
healthunlocked.com/neuro-su...
Barrymart in reply to
Thank you.
in reply to Barrymart
I found an article just doing a google search:
academic.oup.com/neuro-onco...
Barrymart in reply to
Thank you so much.
You might try reading Joe Tippens blog at mycancerstoryrocks. He talks about the dosage that he takes and also talks about others with glioblastomas have had some success. Seems worth a try. Good luck.
One further thing you might try is to add Cimetidine to the Fenbendazole as it seems to have both a synergistic effect with it as well as some anti-cancer effects of it's own. My thoughts are with you for your daughter's well being.
Have you thought about trying mebendazole instead? The study linked by Gregg57 is notable - exciting, really - because it was glioblastoma that these Johns Hopkins scientists were trying to implant in mice with every expectation the cancers would grow - but the mice had also been treated for pinworms with fenbendazole, and the cancer wouldn't grow, and so that particular study instead ended in serendipity. The researchers called for clinical investigation of MBZ for glioblastoma. This study was published 8 years ago; I wonder if that further research has been done.
And this paragraph is very interesting for trying to come up with dosages: "We used a daily dosing for 2 months of 50 mg/kg of MBZ, which translates to 4.1 mg/kg/day based on body surface area. MBZ has been extensively used for human for treating echinococcosis, with multiple reports of minimal adverse effects at 50–70 mg/kg/day for 6–24 months of continuous use. MBZ was also reported safe in children at 100–200 mg/kg doses for 12 weeks.6 These reported safe doses suggest we could escalate to higher doses than those required for efficacy in animals."
I weigh 82 kg and I'm taking 400 mg of MBZ per day, so just under 5 mg/kg/day. At 50 mg/kg/day that would be 4100 mg, or 41 of my 100 mg pills. Far easier than trying to down that much fenbendazole. Cheaper too at 27¢ per pill or about $11/day. I just got 750 MBZ pills from India - at 41 a day they would last about 18 days. Maybe I should try it, see what it does to my PSA.
Glioblastoma is just scary, it's a very tough battle, and I hope for the best for your daughter.
Wow, I have read the exact same information you are sending over. And I am ordering Mebendazole from India right now but it will take about one month to arrive due to holidays with the US Customs, so our NO is allowing us to use Febendazole until it arrives. Our NO is prescribing her to take 4,000mg of Mebendazole daily, so that is what we are going to do. How long have you been taking MBZ and are you seeing any improvement yet? I believe it may well work on our GBM4 as nothing else is working for us. Thank you so much for your help. Also, are you using Affordable Rx Meds.com?
I've only just started MBZ in the last few days - I'd been taking fenben since June, and my PSA has been drifting downward for all but one of the near-monthly blood tests since then. And that's never happened before - when it started going up, it kept going up, and faster, and I'd have to get treatment. This time, well, I haven't felt like I needed treatment yet, so I'm just going to continue and see if my luck holds.
I've never heard of Affordable Rx Meds.com - guess I should look it up.
They had the best price I could find when I did my price shopping on Thursday. God bless you and good luck I hope it turns out well keep me posted. Thank you so very much.
Interesting - your source has the same price I paid directly from India. I looked into the pricing of this drug and was shocked.
We should pray generic mebendazole remains available at this price because the American company (now Amneal Pharmaceuticals) that bought the drug in 2015 raised the price of the brand name (Enverm) from $18.00 for two pills to $1,013.29. Amneal also bought the US rights to albendazole, another drug in the same class with anti-cancer potential, and raised the price to $437. Both of these are available in India and other countries for pennies. Amneal merged with Impax in 2017; Impax is the company that sold the drug Daraprim - for toxoplasmosis and pneumocystis pneumonia - to Turing Pharmaceuticals, whose CEO, the infamous Martin Shkreli, raised the price of a dose from $13.50 to $750 - or $75,000 for a month-long course of treatment.
God bless India. (Ironically, Amneal was founded and is run by two Indian-American brothers.)
I just hope we can continue to source out of India. Blue Cross said they were denying the US version because it would be a cost of $550,000 per month.
these people should be serving life sentences for murder - instead they get away with it...over and over and over again...
ok, enough of that...but going on the assumption mebendazole is going to help, it might be wise if we stocked up on it
1 gram of panacur dog worker with just plain ferbenzenole no copper or other additives everyday for 4 days off it for 3 days or to kick start it everyday for 6 weeks then revert to the pre mentioned protocol
You might want to use Berberine also. It has been shown to block the hedge hog path way in
GBM. I had a sister to pass from GBM. I wish I would have known about alternative treatments for her.
Look at the treatment offered by Novocure. It is a FDA approved treatment for Glioblastoma! Many large prestigious medical institutions are involved in clinical trials for other applications as well. Best of luck.
Barrymart- If you're on Facebook, try the: mycancerstory.rocks group. Quick answers...
Thank you all for the help. I appreciate it.
Hi, my brother just got diagnosed with GBM4 and I am wondering about the Tippens protocol. Would you recommend?
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