Experiences with

Temozolomide

He responded to treatment part 1 and we are now doing standard temozolomide for 6 months but I’m looking for additional treatments approved or not approved.

My dad is on his 2nd cycle of TMZ (300mg)5 days on, 3 weeks off regime. He had GBM located on his left frontal lobe but due to size and depth could not be operated on. Therefore he had 3 weeks of radiotherapy along with 155mg daily TMZ. He has poor speech and his right arm is paralysed. However this

He was later meant to have six months of chemotherapy using a higher dose of Temozolomide. The GBM came back and he had to have surgery (December 2023) to debulk the tumour after only three months of chemotherapy with Temozolomide.

I never had radiotherapy the first time round, just 5/28 cycles of temozolomide for the best part of eight years, and that was full-dose TMZ, not the partial doses.

' Melatonin is also useful for use in people with GBM and also has synergy with temozolomide ( an antineoplastic used for GBM) as discussed here : ' Glioblastoma is the most prevalent primary tumor of brain.

(resection / debulk of 99% in Aug 2021 and then the usual format of care IRO radio, Temozolomide Chemo . Tumour has now returned in 3 places within area debulked.

It is published in the journal Cell Reports They also looked at combining fluoxetine with the gold standard chemotherapy temozolomide The research was in mice only however research will be ongoing My GP is happy to prescribe the medication provided the dose is within BNF prescribing guidelines I

When I’d recovered a bit, they put me on a full strength course of temozolomide for the next eight years. It wasn’t until my old NO retired that a new one came in and really did me a favour - instead of keeping me on the TMZ, he took me off it and hey presto!

TMB is affected by a variety of causes, including exposure to mutagens such as ultraviolet light in melanoma8-9 and cigarette smoke in lung cancer 10-11, treatment with temozolomide-based chemotherapy in glioma12-13, mutations in the proofreading domains of DNA polymerases encoded by the POLE and POLD1

Xeloda, Temozolomide, Packitaxel.

My 16 year old daughter is now fighting a recurrence of GBM4 after proton radiation and Temozolomide failed to control it. We are about to start Fenbendazole and need appropriate dosing information. She weighs 172 pounds. Can anyone give me advice?