Negative results for 12 genetic disorders test. Can anyone elaborate further?

[bellyhappy58]

Just had the above done by Invitae Lab and results for the 12 genetic disorder came out negative ( include ATM, BRCA 1, BRCA 2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, NBN, PMS2, TP53)

The oncologist told me it is good news. Can anyone add any more or elaborate further in relation to Prostate cancer treatment. Thanks

[Tall_Allen]

The good news is you don't have the germline genetic disorders known to be associated with some of the more aggressive types of prostate cancer. There are just a few medicines for those- Keytruda, PARP inhibitors and carboplatin, more in clinical trials. That is not to say that some genetic mutations will not appear later in your metastases.

[bellyhappy58 in reply to Tall_Allen]

Thanks Allen for oyur usual quick response. Noted

[p3d1]

12 seems a low number to test for, there are other Genetic variants that are now becoming bio markers for a PARP treatment, i.e PALB2, ATR, BRIP1,FANC, RAD51 ect.

I would ask for a more detailed test.

[Break60 in reply to p3d1]

What’s the name of this more detailed test. Who performs it?

[ctarleton in reply to Break60]

One of the tests with relatively low expense is the Color test. Here's a link showing the inherited genes it looks at in relation to various cancers.

color.com/learn/color-genes...

Ambry Genetics might be another one to ask about.

ambrygen.com/clinician/gene...

Tall Allen's blog site has lots of other good information about such tests in the context of prostate cancer, too.

pcnrv.blogspot.com/search/l...

(There are other tests that might later be used to analyze mutated tissues in advanced metastatic prostate cancer. Some of these may run into hundreds of genes or variations tested. Such tests may be commercially available, or perhaps done in-house at some of the larger university/research prostate cancer provider sites.)

For the majority of us here, these tests often come back as "negative" and do not really change our overall treatments, but when one does come back "positive", it may influence the choice of future treatment, e.g. if an inherited BRCA gene status is involved, and some kind of PARP Inhibitor might be considered.

Keep asking your doctor. The more you learn, the more likely you will be able to get all of your test/treatment options out onto the table. Good Luck!

Charles

[p3d1 in reply to Break60]

ctarleton has answered your question above.

The better tests check for over 300 biomarkers. It would be a mistake to concentrate on only the "Top 12".

PALB2 is possibly going to prove as valid a biomarker in the near future as BRCA2. FANCA and BRIP1 showed a very good response as part of the Triton2 trial last year. This data will be updated at ESMO 2019 in Barcelona which is reporting this weekend. We need for Oncologist to start talking to the experts in testing for prostate cancers specific markers.

Even though these faulty genes may only affect a small percentage for many. If you get one of these results back as a loss, it may help with your treatment.

Best of luck.

[bellyhappy58 in reply to p3d1]

Will reach out to the oncologist when I see hom next. Thanks

[j-o-h-n in reply to bellyhappy58]

And don't forget the parallel parking test.... The older we get the harder to pass it....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 09/27/2019 6:05 PM DST