Genetic Testing Results: Bad image, but... - Advanced Prostate...

Advanced Prostate Cancer

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Genetic Testing Results

Sipj profile image
Sipj
20 Replies

Bad image, but what does this mean?

“This test does not identify any pathogenic variants known to cause disease”

Does it just mean it was not inherited? And how will this help with treatment?

Thank you for any insight.

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Sipj profile image
Sipj
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20 Replies
Tall_Allen profile image
Tall_Allen

It's good news. It means you have no inherited mutations that are known to be associated with disease. That is what is most often found. It doesn't help with treatment.

joeguy profile image
joeguy

I had a blood genetic test from Myriad (I think) a couple years ago and it also showed no genetic mutations that would be associated with prostate cancer. I found that curious considering my great grandfather, father, brother, and uncle (on fathers side) all had prostate cancer.

LearnAll profile image
LearnAll in reply tojoeguy

Joe...either you are a lucky son of a gun....that did not get germline mutations OR the testing lab made an error. I would repeat the test.. preferably with a reputed lab like Color.com.

joeguy profile image
joeguy in reply toLearnAll

Arent some of the mutations, like the BRCA for example, considered to be somewhat helpful in that they open up more treatment options for immuno-therapies or PARP inhibitors?

dadzone43 profile image
dadzone43 in reply toLearnAll

What makes Color.com "reputed"? That they advertise? That they send out big, glossy mailings? All of these are for-profit ventures. Caveat emptor.

SViking profile image
SViking in reply todadzone43

I'm curious about this company too. I just sent back a saliva sample for a "Free analysis" based on a recommendation on this site about being part of a survey. This company did send a free test kit but we shall see if there is an up-sell involved.

Magnus1964 profile image
Magnus1964

There are some treatments for PC caused by genetic mutation. You are not eligible for these. So the standard treatments will be used.

Sipj profile image
Sipj

Thanks everyone- that is what I thought. Although it is strange because my husband’s father and maternal grandfather both had prostate cancer diagnosis in their 60’s.

tango65 profile image
tango65

One has to considers that a mutation may have many variants, BRCA 1 and BRCA 2 have more than 20,000 variants.

nih.gov/news-events/news-re...

The results of a genetic test may say that one does not have any mutation related to known diseases but it is true only for the analysis that was done and how many variants known to be associated with disease for important mutations were studied, This problem may be common in tests like 32 and me and similar.

This is a complex subject you need to consult with an expert in genetics, to see if further analysis of the genome should be done.

Shooter1 profile image
Shooter1

My first genetic testing 4 years ago showed nothing actionable of the 67 they checked... My last (2nd) genetic testing of CTC showed only 2 mutations with a load of only 0.46, really low and nothing PARP inhibitors could act on... Just lucky (unlucky) to get aPca for unknown reasons. Life Is Good, standard treatments for me too.

AlanMeyer profile image
AlanMeyer

Hello Sipj,

As I understand it, it used to be the case, and most likely still is, that various testing labs chose particular DNA patterns for testing based on their understanding of what DNA patterns are associated with prostate cancer and how detectable those patterns may be. Both helpfully, and not so helpfully, the science of all of this is under continuing change, so two different labs, or one lab at two different times, may report "actionable" mutations differently. It's an evolving science that has produced some life extension for some patients, but it's not yet an exact science.

Alan

MateoBeach profile image
MateoBeach

I would ask them to send you all of the specific genes they tested for mutations for your own documentation. Especially with your family history. You may need a more sophisticated comprehensive panel. And test for somatic (acquired tumor) mutations if you have tumor tissue from RP or biopsy.

Ramp7 profile image
Ramp7

It means at the present no known identified variants have been noted. This can change with time as more variants are identified.

Hotrod65 profile image
Hotrod65

no somatic Germlines noted...in other words, nothing passed down thru family Genes that would contribute to your disease..next step to inquire about would be Genomic testing or sequencing of actual tissue to determine the Molecular makeup of the cancer pathology or the DNA varients that might be a match for any number of targeted therapies specific to your case...it has been a lifesaver for me, I'm well connected with Foundation Medicine as a patient advocate and can refer you to the proper folks to inquire about testing after it's discussed with your own Medical Team.

Sipj profile image
Sipj in reply toHotrod65

Thank you, good to know.

OTPrincess profile image
OTPrincess

We had Invitae testing and it said there was a variation on brca 2 gene. Not a mutation. Missing an amino acid but they could not say if it was disease related either. Well…I’m guessing it is! Hello. Aggressive prostate cancer. Also couldn’t tell us if it was hereditary or environmental. Very disappointed in the report but maybe our medical oncologist will find something of value in it. We kind of knew this already from germ line testing in the biopsy cores.

j-o-h-n profile image
j-o-h-n

My test came back with just one word "HANDSOME".....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 11/25/2021 6:57 PM EST

dadzone43 profile image
dadzone43

You did the same as I. I already had DNA testing from another source after I was diagnosed with PCa.

Faith1111 profile image
Faith1111

My brother did not have inherited mutations however with time he developed somatic mutations. He did a blood biopsy. Foundation One returned a comprehensive report showing genes tested. It was determined he would be a good candidate for Keytruda. He has been on it for 7 months. A third biopsy was just done as his mo is curious to see what it shows now. So you may want to repeat after a period of time.

Sipj profile image
Sipj in reply toFaith1111

That’s interesting that it mutates. Thank you for the information.

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