18F-fluciclovine PET-CT and 68Ga-PSMA-11 PET-CT in patients with early biochemical recurrence after prostatectomy: A prospective, single-...

[GranPaSmurf]

The use of PSMA PET-CT scans resulted in higher detection rates, and therefore, this diagnostic modality was recommended when PET-CT imaging is considered for subsequent treatment management decisions in patients with prostate cancer and biochemical recurrence after radical prostatectomy and low PSA concentrations ( ≤ 2·0 ng/mL).

thelancet.com/journals/lano...

[Fairwind]

Ga-68 is very expensive and difficult to make. It has a very short half-life and must be used as soon as it's made (in a cyclotron) Using it routinely presents a lot of problems.. The big question is, in the end, does the patient live any longer because of it ? Or does super-early detection just lead to super-expensive treatments that in the end, make only a marginal difference in the patients overall survival time..?

[GranPaSmurf in reply to Fairwind]

Good point, thanks

[Hidden]

There is also the newer 18F-PSMA-1007 PET/CT claimed to exhibit some advantages over the 68Ga-PSMA-11 PET/CT (more readily available, etc).

IMHO the prime pro is that it doesn't mask (sciagraphicaly) the bladder and everything behind it (it metabolizes via the liver, while 68Ga follows the urinary track).

In the case of an RP, the anastomosis is a potentially suspicious area, where this ligand provides enhanced dynamic range.

[GranPaSmurf in reply to Hidden]

With the way progress is being made, it looks like our younger brothers will be able to diagnose and treat much sooner.

And my grandsons!

[bean1008]

I know it's been a couple of months since this was posted...has anyone found where they might get a 18F PSMA PET scan? I'm coming up blank on searches...and it sounds superior to the G68.

Thanks