More Lu-177 Vision Trial observations..

[Fairwind]

Any of you men out there who are getting the Lu-177 treatment, any noticeable side-effects that you can attribute directly to the Lu-177 injection itself ? How long did it take before any improvement in your cancer was observed ? I just had my first dose and am in the "3-day isolation" now..Feel sort of crappy..No appetite, no energy or ambition.. I'm getting no co-treatments except Eligard for the time being. They want to see how I respond to the Lu-177 by itself..

[GP24]

The main side effects are a dry mouth and fatigue. This page discusses side effects in more detail:

klinikum.uni-muenchen.de/Kl...

To check the response I would get a PSA test in about four weeks. The PSA value should be lower than before the treatment. Also, your doctors will have scheduled another PSMA PET/CT to see if your mets have shrunk or have disappeared from the PET scan.

[CJ4J]

My husband has had 5 treatments now. He would feel extremely tired after the first 24 hours, felt a little discomfort in the areas of known tumors but was fine in a few days. He said he could feel it working. No other side effects since then. He only felt that on the 1st two treatments. But everyone reacts differently depending on your current health and tumor load.

Hope you feel better soon.

[Jackpine]

Fair wind,

When I started LU177 the first injection knocked me down for about a week with bone pain, fatigue, and loss of appetite. After about a week I started feeling much better although my appetite was less I found eating fruit tasted the best. For me my PSA dropped from 110 to 80 after the first injection then increased some on the second then dropped to a low of 0.4 at the end of the 4th injection. I hope you have the same type of results as I did as I feel the best I have since being diagnosed almost 6 yrs ago.

For me side effects after the first injection were minimal and my appetite has retuned to normal. I finished 6 injections in May and will have new scans next week to see where the cancer is still active as my PSA has risen to 2.5 although much slower than before treatment.

Stay strong!!

[j-o-h-n in reply to Jackpine]

Congratulations... As as the wife said to husband when she was on top "keep UP the good work Jack"...

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/29/2019 5:14 PM DST

[Jackpine in reply to j-o-h-n]

LOL!! One can dream!

Hope you are having a great summer!

[j-o-h-n in reply to Jackpine]

For you a dream, for me a nightmare....

HOT HOT HOT summer.... hope yours is comfortable...... thank you..

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/29/2019 7:32 PM DST

[1965l79Corvette in reply to Jackpine]

How are yu now?

Thanks

[Mohopes]

My husband had the combo Lu-177/Ac-225 treatment. After his first treatment he felt horrible. For the first week he had nausea, extreme fatigue, no appetite, depression, didn't want to get out of bed. It was worse than chemo side effects. For the next three weeks he had a reaction known as tumorlysis, a syndrome that develops when too many dead cancer cells build up in the bloodstream and can't be filtered out fast enough by the kidneys. It is a dangerous side effect as it can damage or even shut down the kidneys. During that three weeks he a host of bizaare side effects that included physical stuff like the fatigue and joint aches and pains where the tumors were, but also personality changes and psychological effects. He had bouts of anger and violent frustration that are atypical to his personality and even memory impairment. It was a scary time for all of us. All the symptoms stopped at almost four weeks on the dot and then he felt super for about two weeks. Two weeks after that until we left for Germany again, he started to go downhill with cancer symptoms. We made the trip anyway and he got the second treatment. This time his side effects weren't so severe or prolonged.

[MeliaQuinn in reply to Mohopes]

That sounds very scary! I hope he is doing much better. Are you going to continue with the treatments? Please keep us updated.

[Mohopes in reply to MeliaQuinn]

MeliaQuinn, no we aren't. Please see my very long post detailing our experience. Just posted.

[Reader456]

My husband's side effects were fairly mild - fatigue (just like all of the other treatments) achy and flu-like for a few days. That went away. Some bone pain - which they said can be the LU-177 hitting the mets. He did notice that his BP went up, so was started on a low dose blood pressure medication. His PSA started taking huge jumps so he dropped out of the Vision Trial prior to the 5th treatment. 6 1/2 weeks after his 4th treatment, his blood pressure dropped - dizzy, nauseous... Went off the blood pressure medication, and all that has stabilized. So LU 177 treatments may increase blood pressure.