Association Between Androgen Deprivat... - Advanced Prostate...

Advanced Prostate Cancer

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Association Between Androgen Deprivation Therapy Use and Diagnosis of Dementia in Men With Prostate Cancer

GranPaSmurf profile image
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jamanetwork.com/journals/ja...

Conclusions

In summary, our population-based study spanning 10 years or more following the diagnosis of prostate cancer shows that exposure to ADT was associated with increased hazard of both Alzheimer disease and dementia among elderly

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GranPaSmurf profile image
GranPaSmurf
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Tall_Allen profile image
Tall_Allen

Unfortunately, these database studies tell us little. From my files:

"In this population-based study, the use of ADT was not associated with an increased risk of dementia. "

ascopubs.org/doi/full/10.12...

"These data suggest that ADT treatment has no hazard for Alzheimer's Disease and no meaningful hazard for dementia among men age 67 years or older who are enrolled in Medicare."

ascopubs.org/doi/full/10.12...

"We concluded that there was no difference in the risk of subsequent dementia between PC patients who did and those who did not receive ADT."

ncbi.nlm.nih.gov/pmc/articl...

"Our analysis of FDA MedWatch adverse event data reports does not support the idea that androgen deprivation therapy per se is associated with Alzheimer’s disease or cognitive dysfunction."

ncbi.nlm.nih.gov/pmc/articl...

"Among older men with low testosterone and age-associated memory impairment, treatment with testosterone for 1 year compared with placebo was not associated with improved memory or other cognitive functions."

ncbi.nlm.nih.gov/pmc/articl...

j-o-h-n profile image
j-o-h-n

Based on my memory, it's true.... I forget common words..... but I never forget the four letter ones....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 07/06/2019 7:44 PM DST

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