Docs should consider a patient's weight before prescribing new chemotherapy drugs

[cesanon]

Docs should consider a patient's weight before prescribing new chemotherapy drugs

medicalxpress.com/news/2019...

A new class of cancer drugs just now entering the marketplace seems promising so far, but researchers at the University of Illinois at Chicago urge doctors to take into account a patient's weight and liver status before prescribing them once they come on the market

Not about prostate cancer specifically, but we were talking about adjusting dose to body weight, and paying attention to liver condition.

[timotur]

I do a wt-adj dose with all prescribed drugs being a small person at 145 lbs. Zytiga: 1/2 dose per day with tsbp yogurt, Lupron: monthly shot every six weeks. Seems to be working so far, PSA < 0.1 one month after HDR-BT.

[ctflatlander in reply to timotur]

Congrats, Did you adjust Zytiga due to liver toxicity or purely your weight?

Thankyou.

[timotur in reply to ctflatlander]

Purely on weight, based on average US male ave weight of 197lbs. First month on full dose of Zytiga liver enzymes bumped up to about 1.5 ULN, not extraordinary. Following month on 3/4 dose they got better, and now on 1/2 dose all are in range. Still taking 2x2.5mg Prednisone. Taking Zytiga with a bit of yogurt to boost the dose. Read that lower doses within range of full efficacy actually increase time to CR. Further read that European standard for Lupron is 11.5mg per three months, 1/2 the US dose.

[Cynthgob in reply to timotur]

Where did u read that?

[timotur in reply to Cynthgob]

wired.com/story/cancer-trea...