How fast does psa fall after loadin d... - Advanced Prostate...

Advanced Prostate Cancer

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How fast does psa fall after loadin dose of firmagon

Dachshundlove profile image
14 Replies

We are just over 1 month from initial shot, and my husbands psa is at 10.24

Prior to his biopsy it was 19.98 (6 weeks ago) and we never tested it post biopsy (I assume it went up from biopsy trauma). So prior to shots we had no baseline.

Love to all of you.

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Dachshundlove profile image
Dachshundlove
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14 Replies

Let his Psa drop to undetectable ... firmagon works well ..stay positive .

Magnus1964 profile image
Magnus1964

Give it a few months and see where the PSA is going, what is the "trend",

Dachshundlove profile image
Dachshundlove in reply to Magnus1964

Thank you for the reminder Magnus1964. Your exceptional story gives us all hope.

Fairwind profile image
Fairwind

The Firmagone does not directly lower PSA...It's the greatly reduced Testosterone that lowers the PSA. So when they do his next blood work, ask that they check his "T" level to be sure it has responded as expected. I would hope for below 10 for best results..Some say below 20..

Dachshundlove profile image
Dachshundlove in reply to Fairwind

I’ll ask for a testosterone test at the next appt. He has never had one so we don’t have a clue what it was prior to firmagon. Thank you!

tango65 profile image
tango65

Firmagon decreases testosterone to castration levels in the first 24-48 hours. The rate of PSA fall after starting ADT depends on each cancer. The time to PSA nadir may be associate with the time it takes the cancer to become castration resistant.

journals.lww.com/md-journal...

Dachshundlove profile image
Dachshundlove in reply to tango65

Thank you— I’m hoping that this indicates something positive for him (as opposed to firmagon doesn’t work well for him)

I’m trying to be one day at a time but I read about the poor guys who nothing works for and my mind instantly goes to that when I see the results today.

tango65 profile image
tango65 in reply to Dachshundlove

I hope he will get to an undetectable nadir in few months. Best of luck.!!!

Tippler profile image
Tippler

The Firmagon worked for me within hours from the injection. Prior to that, I could not sleep because of pain in the pelvic area, I had to stop driving because of the pain. I could not sit without discomfort/pain at home, in church. Two months later I was put on Zytiga and Prednisone and the Firmagon was replaced with Lupron, now Eligard every three months. The PSA continued to decrease. The Firmagon took the pain away in May of 2018 and it stayed away! My Sonny is 25% Dachshund and our love is above 100%! Good luck!

Hirsch profile image
Hirsch in reply to Tippler

I had a 24 to 48 hour response to first shot of Firmagon..

the symptoms of urinary obstruction were improved significantly..

My urologist at the time did not believe me..

It's faster acting than Lupron.

j-o-h-n profile image
j-o-h-n

Patients is a virtue, have it if you can, never in a woman, always in a man.... ❤ I think I'm in deep kaka....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 06/20/2019 4:57 PM DST

farm15 profile image
farm15

I was on Firmagon for 12 months stopping in April and last blood test PSA is still undetectable in June 0.06 it has been very effective in shutting down testosterone production. I would expect PSA levels to drop quickly. I am a gleason 9 as well.

Stay Strong.

testr profile image
testr

The following is from memory:

(I think this was approx 3 weeks after my 1st shot.)

Before 1st shot of Firmagon: T =~350

After 1st shot of Firmagon: T=18

Note that my T drop was very dramatic,

but my PSA dropped by only just about half.

(Tip: Using an ice pack prior to the Firmagon belly shot helps some.)

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