Coronavirus: articles and preprints
Sign in or create an account
Europe PMC
Menu
About
About Europe PMC
Preprints in Europe PMC
Funders
Joining Europe PMC
Governance
Roadmap
Outreach
Tools
Tools overview
ORCID article claiming
Journal list
Grant finder
External links service
RSS feeds
Annotations
Annotations submission service
Developers
Developer resources
Articles RESTful API
Grants RESTful API
API use cases
SOAP web service
Annotations API
OAI service
Bulk downloads
Developers Forum
Help
Help using Europe PMC
Search syntax reference
Contact us
Europe PMC plus
Search worldwide, life-sciences literature
Search
Advanced Search Coronavirus articles and preprints
Search examples: "breast cancer" Smith J
Association between periodontal disease and prostate cancer: a systematic review and meta-analysis.
Wei Y1, Zhong Y, Wang Y, Huang R
Author information
Medicina Oral, Patologia Oral y Cirugia Bucal, 28 Nov 2020,
DOI: 10.4317/medoral.24308 PMID: 33247563
Share this article Share with emailShare with twitterShare with linkedinShare with facebook
Abstract
BACKGROUND:Periodontal disease is a chronic infectious disease caused by bacterial infection which may lead to various systematic diseases. Recently, increasing studies have explored the correlation of periodontal disease with the risk of prostate cancer. However, the findings were inconsistent. Hence, this study aims to investigate the association between periodontal disease and the risk of prostate cancer by a meta-analysis. MATERIAL AND METHODS:PubMed, EMBASE, and Cochrane were searched for publications up to July 17, 2020. Cohort and case-control studies evaluating the risk of prostate cancer in patients with periodontal disease were included. A fixed or random-effect model was used to calculate the summary relative risk (RR) along with 95% confidence interval (CI). All analyses were conducted using Stata 12.0 software. RESULTS:Seven studies were included in the final analysis. The pooled estimates showed that periodontal disease was significantly associated with the risk of prostate cancer (RR = 1.17; 95% CI = 1.07-1.27; P = 0.001). Findings of sensitivity analyses proved that the overall results were robust. CONCLUSIONS:Periodontal disease may be considered as a potential risk factor for prostate cancer. Although it's a possibility, males should be more aware of their oral health and implement effective measures to prevent and treat periodontal disease.