Milk

[pjoshea13]

New German study involving Bavarian adults drinking milk below [1].

When milk was first associated with more aggressive PCa, there were a number of potential suspects. There is a good case for calcium, but the obvious culprit was IGF-I (insulin-like growth factor I). Anything with "growth factor" in the name should ring warning bells to anyone with cancer.

The dairy industry responded as industries tend to do with denials. It would be catastrophic to the industry if people thought that milk caused cancer.

I have read that IGF-I is destroyed in the stomach. Surely, bio-identical IGF-I in human milk isn't destroyed? That heat-teatment of milk destroys almost all IGF-I. That there is very little IGF-I in milk, compared to human blood. That there is more IGF-I in saliva than milk (be very careful when kissing!) And so on. But, finally: IGF-I is not associated with any cancer, except, possibly, cancer of the prostate. Apologies for not hunting down sources.

From the study:

"Each 400 g increment in daily dairy intake was associated with 16.8 µg/L ... higher IGF-1 concentrations. Each 200 g increment in milk per day was associated with 10.0 µg/L ... higher IGF-1."

Doesn't state what the percentage increases were.

Good news for cheese lovers:

"In contrast, we observed no association between cheese or yogurt intake and IGF-1 concentrations."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/310...

Eur J Nutr. 2019 May 14. doi: 10.1007/s00394-019-01994-7. [Epub ahead of print]

Association of dietary intake of milk and dairy products with blood concentrations of insulin-like growth factor 1 (IGF-1) in Bavarian adults.

Romo Ventura E1,2, Konigorski S1,3, Rohrmann S4, Schneider H5, Stalla GK6,7,8, Pischon T1,9,10,11, Linseisen J12,13, Nimptsch K14.

Author information

1

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.

2

Department of Infectious Disease Epidemiology, Respiratory Infections Unit, Robert Koch-Institute, Berlin, Germany.

3

Digital Health and Machine Learning Research Group, Hasso Plattner Institute, Potsdam, Germany.

4

Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

5

Center for Endocrinology and Metabolism, Munich, Germany.

6

Medicover Neuroendocrinology, Munich, Germany.

7

Clinical Neuroendocrinology, Max-Planck-Institute, Munich, Germany.

8

Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität, Munich, Germany.

9

Charité Universitätsmedizin, Berlin, Germany.

10

Berlin Institute of Health, Berlin, Germany.

11

DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.

12

Chair of Epidemiology, Ludwig-Maximilians-Universität München, at UNIKA-T Augsburg, Augsburg, Germany.

13

Clinical Epidemiology, Helmholtz Zentrum München, Munich, Germany.

14

Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany. [e-mail].

Abstract

PURPOSE:

Circulating IGF-1 concentrations have been associated with higher cancer risk, particularly prostate, breast and colorectal cancer. There is evidence from observational and intervention studies that milk and dairy products intake is associated with higher IGF-1 concentrations, but results were not always consistent. The purpose of this study was to examine the relationship between dairy intake and circulating IGF-1 concentrations in participants of the Second Bavarian Food Consumption Survey, thereby providing data for a German population for the first time.

METHODS:

In this cross-sectional study of 526 men and women aged 18-80 years, in contrast to most previous investigations, dietary intake was assessed with a more detailed instrument than food frequency questionnaires (FFQs), i.e., by three 24-h dietary recalls conducted on random days close in time to the blood collection. Circulating IGF-1 concentrations were measured in blood samples. Multivariable linear regression models were used to examine the association of dairy intake with IGF-1 concentrations.

RESULTS:

Each 400 g increment in daily dairy intake was associated with 16.8 µg/L (95% CI 6.9, 26.7) higher IGF-1 concentrations. Each 200 g increment in milk per day was associated with 10.0 µg/L (95% CI 4.2, 15.8) higher IGF-1. In contrast, we observed no association between cheese or yogurt intake and IGF-1 concentrations.

CONCLUSIONS:

Our findings are in line with most previous investigations and support the hypothesis that dairy and milk intake are associated with higher IGF-1 concentrations.

KEYWORDS:

24-h dietary recall; Dairy; IGF-1; Milk

PMID: 31089868 DOI: 10.1007/s00394-019-01994-7

[AnnieAppleseed]

Drink milk, if any adult must, from free-range, pasture-fed animals, not raised with bovine growth hormone, antibiotics or other hormones added.

[rococo]

I am suspicious of any food that feeds the developing animals egg yokes for chickens and milk for mammals when cells are deciding at a rapid rate like cancer but benign, turned off at maturity. Food for thought. Rocco

[pjoshea13 in reply to rococo]

Milk is unique in that it contains the nutrients approriate for growth - plus a hormone to promote growth (IGF-I). (Why doesn't a baby secrete enough IGF-I?)

A PubMed search for <prostate "IGF-I"> returned 523 hits.

A big area of interest to me is the insulin axis. PCa is the only cancer where burn-out of pancreatic beta cells (the insulin producers) is protective. The only cancer where diabetics have lower risk.

Many men diagnosed with PCa have some degree of pre-diabetes - their beta cells are working overtime in response to insulin resistance. Doctors don't really care about that - most pre-diabetics don't actually become diabetic.

"High levels of insulin decrease the production of IGF-1 binding proteins and hence increase levels of free IGF-1. It is well established that bioactivity of free insulin growth factor 1 (IGF-1) increases tumor turnover rate." [1]

-Patrick

[1] bmcendocrdisord.biomedcentr...

[tom67inMA in reply to pjoshea13]

This is a bit of a bummer, as I've also heard insulin helps with muscle recovery and growth after exercise. It seems very hard to maintain lean mass without feeding the cancer in some way.

[pjoshea13 in reply to tom67inMA]

Tom,

Quite a few years ago, the topic came up in another group. Seems that there was a case for IGF-I being produced locally in affected muscle, after exercise, rather than systemically.

Interestingly: "After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%." [1]

(IGF binding proteins, such as IGFBP-1, reduce levels of free IGF.)

Elsewhere, more intense exercise has been reported to raise blood IGF-I. However: "It would appear that the increase in circulating levels of both IGF-I and its binding protein IGFBP-1 is a short term (one week) endocrine adaptation to endurance exercise. After three weeks of training, total IGF-I and IGFBP-1 remained stable, whereas free IGF-I fell below starting levels." [2]

-Patrick

[1] hindawi.com/journals/ije/20...

[2] bjsm.bmj.com/content/35/5/303

[tom67inMA in reply to pjoshea13]

Thanks for the links! Describing la vuelta a espana as "endurance exercise" is the understatement of the century, ROFL!

So is it fair to say that any type of exercise eventually results in improvements in insulin sensitivity and decreases system levels of free IGF? (which I assume is the form that matters, and that bound IGF isn't bioactive)

[pjoshea13 in reply to tom67inMA]

Tom,

"bound IGF isn't bioactive"? Correct. Normally, a lot of IGF-I is inactive because it is bound to IGFBP-3. PCa is able to reduce levels of that binding protein, thereby increasing free IGF-I.

Even brief periods of intense exercise profoundly affects blood chemistry. The metabolic syndrome may seem to be inevitable while on ADT, but Dr. Myers once said that he could always tell which patients had been exercising.

-Patrick

[tom67inMA in reply to pjoshea13]

Ah, so intense exercise increases the levels of binding protein and thus reduces free IGF, got it. Thanks again!

[GeorgeGlass in reply to pjoshea13]

Patrick, What level of intensity would be best for lowering free IGF-I, low, moderate or high intensity?

Exercising while still on a daily 17/7 fast should help suppress the cancer even more, right?

George

[pjoshea13 in reply to GeorgeGlass]

Hi George,

I'd be guessing.

-Patrick

[treedown in reply to GeorgeGlass]

For me I could never maintain my level of exercise and fast. Maybe when winter comes and my exercise gets reduced by weather and available light. I am of course assuming I can keep this up but I am riding farther and faster than pre dx so as far as I am concerned that will continue as long as possible. This seems to suggest that if your per dx health isn't a factor ADT does not have hold back increased fitness.

[GeorgeGlass in reply to treedown]

i dont have anything holding me back expect coronary artery disease and Levaquin poisoning. But, I'm still exercising even thought the poisoning damaged my cells permanently.

[treedown in reply to GeorgeGlass]

What is Levaquin ?

[CalBear74]

I infer from your report that eating cheese is not risky given the IGF-1 absence in those subjects. Is that true? As a vegan, and former cheese freak, I am looking for evidence that I can occasionally have some and it would not be carcinogenic. Can you help me Patrick? Do you eat cheese?

[pjoshea13 in reply to CalBear74]

Every now & then I get the urge. I'm drawn to aged cheeses but I often go for a triple-crème cheese. I reason that the calcium & IGF-I might be higher in the protein than in the fat. The case for richer cheeses is that one does not need to eat a lot to be satisfied.

I think that almost any "bad" food can be justified if it is eaten infrequently & raises QoL. Of course, that doesn't mean that I would eat a different bad food every day for a month & think it was OK.

-Patrick

[j-o-h-n]

Got Milk?

youtube.com/watch?v=OLSsswr...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 05/18/2019 11:11 AM DST

[j-o-h-n]

So I took off my shirt and I'm standing in front of the mirror admiring my man boobs... when my wife commented "Got Milk?"...........(I smacked her as I usual do - she's starting to like it)....Geezamacripe

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 05/18/2019 11:54 AM DST

[HopingForTheBest1]

Try dairy free almond milk as a great alternative.

[j-o-h-n in reply to HopingForTheBest1]

"Try dairy free almond milk as a great alternative?" THAT'S NUTS...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 05/19/2019 1:49 PM DST

[CrocodileShoes]

I've been on and off diary over the years. Since my PCa returned, I've been advised off anything that's basically white: sugar, dairy and refined wheat. That said , I occasionally lapse with a bit of cheddar cheese. So, that's reassuring to know.

I find almond milk does everything cow's milk does in my diet.