New German study involving Bavarian adults drinking milk below [1].
When milk was first associated with more aggressive PCa, there were a number of potential suspects. There is a good case for calcium, but the obvious culprit was IGF-I (insulin-like growth factor I). Anything with "growth factor" in the name should ring warning bells to anyone with cancer.
The dairy industry responded as industries tend to do with denials. It would be catastrophic to the industry if people thought that milk caused cancer.
I have read that IGF-I is destroyed in the stomach. Surely, bio-identical IGF-I in human milk isn't destroyed? That heat-teatment of milk destroys almost all IGF-I. That there is very little IGF-I in milk, compared to human blood. That there is more IGF-I in saliva than milk (be very careful when kissing!) And so on. But, finally: IGF-I is not associated with any cancer, except, possibly, cancer of the prostate. Apologies for not hunting down sources.
From the study:
"Each 400 g increment in daily dairy intake was associated with 16.8 µg/L ... higher IGF-1 concentrations. Each 200 g increment in milk per day was associated with 10.0 µg/L ... higher IGF-1."
Doesn't state what the percentage increases were.
Good news for cheese lovers:
"In contrast, we observed no association between cheese or yogurt intake and IGF-1 concentrations."
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/310...
Eur J Nutr. 2019 May 14. doi: 10.1007/s00394-019-01994-7. [Epub ahead of print]
Association of dietary intake of milk and dairy products with blood concentrations of insulin-like growth factor 1 (IGF-1) in Bavarian adults.
Romo Ventura E1,2, Konigorski S1,3, Rohrmann S4, Schneider H5, Stalla GK6,7,8, Pischon T1,9,10,11, Linseisen J12,13, Nimptsch K14.
Author information
1
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.
2
Department of Infectious Disease Epidemiology, Respiratory Infections Unit, Robert Koch-Institute, Berlin, Germany.
3
Digital Health and Machine Learning Research Group, Hasso Plattner Institute, Potsdam, Germany.
4
Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
5
Center for Endocrinology and Metabolism, Munich, Germany.
6
Medicover Neuroendocrinology, Munich, Germany.
7
Clinical Neuroendocrinology, Max-Planck-Institute, Munich, Germany.
8
Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität, Munich, Germany.
9
Charité Universitätsmedizin, Berlin, Germany.
10
Berlin Institute of Health, Berlin, Germany.
11
DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.
12
Chair of Epidemiology, Ludwig-Maximilians-Universität München, at UNIKA-T Augsburg, Augsburg, Germany.
13
Clinical Epidemiology, Helmholtz Zentrum München, Munich, Germany.
14
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany. Katharina.Nimptsch@mdc-berlin.de.
Abstract
PURPOSE:
Circulating IGF-1 concentrations have been associated with higher cancer risk, particularly prostate, breast and colorectal cancer. There is evidence from observational and intervention studies that milk and dairy products intake is associated with higher IGF-1 concentrations, but results were not always consistent. The purpose of this study was to examine the relationship between dairy intake and circulating IGF-1 concentrations in participants of the Second Bavarian Food Consumption Survey, thereby providing data for a German population for the first time.
METHODS:
In this cross-sectional study of 526 men and women aged 18-80 years, in contrast to most previous investigations, dietary intake was assessed with a more detailed instrument than food frequency questionnaires (FFQs), i.e., by three 24-h dietary recalls conducted on random days close in time to the blood collection. Circulating IGF-1 concentrations were measured in blood samples. Multivariable linear regression models were used to examine the association of dairy intake with IGF-1 concentrations.
RESULTS:
Each 400 g increment in daily dairy intake was associated with 16.8 µg/L (95% CI 6.9, 26.7) higher IGF-1 concentrations. Each 200 g increment in milk per day was associated with 10.0 µg/L (95% CI 4.2, 15.8) higher IGF-1. In contrast, we observed no association between cheese or yogurt intake and IGF-1 concentrations.
CONCLUSIONS:
Our findings are in line with most previous investigations and support the hypothesis that dairy and milk intake are associated with higher IGF-1 concentrations.
KEYWORDS:
24-h dietary recall; Dairy; IGF-1; Milk
PMID: 31089868 DOI: 10.1007/s00394-019-01994-7
Protein intake and longevity
