When The American Cancer Society post this - do they mean when treatment is given or not given? - if these stats are when treated, what treatments do they mean?
The 5-year survival rate for most men with local or regional prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years. For men diagnosed with prostate cancer that has spread to other parts of the body, the 5-year survival rate is 30%.
Can you provide a reference? It probably is across ALL men with a PC diagnosis, whether treated or not. Median overall survival in the placebo+standard-of-care group of newly diagnosed, metastatic men was about 4 years.
This might be the primary arcane reference.
seer.cancer.gov/archive/csr...
Last page, Figure 23.7, reading the data bars for "0 years (at diagnosis)".
Hi TA,
Can you please provide reference or link to your blog about this 4 year findings? I'm building my research backend repository, just to ignite my docs...
That's from the STAMPEDE trial.
Is this 4-year median for PC-specific survival?
TA - thanks, do u have the NCI reports confirming this? thanks...
It's not from NCI reports
TA - what clinical source are you using for ur response?
It was from the control group from the STAMPEDE trial of abiraterone in newly diagnosed metastatic men.
The link, please....
Ken,
Likely this is old news ...Zytiga was approved in Dec, 2012 for castrate resistant prostate cancer.... since then apalutamide, enzalutamide, Xofigo, Xgeva, and others in phase 3....immunotherapy....I read that initially and freaked out....I wish I could stop thinking about this for a day...I do have times at work when I go for hours....I asked my MO and he said 5-10 years, who knows ??
Fish
Yes these stats are looking at king in the rear view mirror for sure. Early treatments including adding chemo or Zytega to adt have already shown huge survival benefits since.
Schwah.
I think about it myself seems likenin stop. I am retired now so it’s on my mind ALL the time. I don’t even know how to characterize my stage at this point or what to call it.
hey Fish - no one knows with any firm level of certainty - that's why I'm very supportive of nomograms and AI.... I asked my RO what if SRT failed a few months ago --- he said we have all kinds of options --- might sound distrustful and I probably am - but I feel like a revenue stream for them...not sure I'm playing along with that. My PCP of 25 yrs says he has seen guys at 40 plus PSAs doing just fine... so confusing...
don't even go by the numbers everyone is different and the cancer does its thing with all the different men out there
charlie
The #s are there based on something clinical - that's what I was looking for... if u have it, share ..thanks and best of luck 2 u. Ken
I used to be the same. obsessing over the time I have left. I'm far far better now. Maybe a combination of time passed, keeping myself busy and distracted, exercise and diet, and reading more about the disease and all the promising new findings are helping me along.
Look at the graphs towards the end of the article for all sorts of survival analysis from STAMPEDE. It's broken down by category. One thing to keep in mind: NOBODY is a median.
nejm.org/doi/full/10.1056/N...
Interesting, by July 2017, there was almost 30% who were still on zytiga and Lupron that had not had a treatment failure at the time of that paper...about 5 years, 7 months....that is pretty sweet...guess that's why my MO guessed ----"5-10 years, who knows?".. If only some of the new line of ADT drugs that block AR mutations succeed, then the OS will increase significantly...
Well technically, if there's 9 men in a study, by definition the 5th one to die IS the median. 
But the point is still valid. 50% of subjects will live longer than the median, sometimes a lot longer.
Now you're getting technical!
My point being everyone is different. And you are right, the AVERAGE is far above these numbers. All these stats exclude all new therapies that is flourishing now with PSMA_LU/AC, Radium234, and a host of checkpoint inhibitors and immunotherapy.
thanks snoraste will do - can't leave my life obsessing over a minor PSA jump.
Ken,
In the U.S., overscreening has inflated the number of cases. This has the effect of making the survival stats look superior to other parts of the world.
In the U.K., where there is less screening, overall 5-year survival is 84.8% [1].
Although this varies by age at diagnosis (92% for age 50-59, down to 59% for age 80-89).
As in the U.S. the rate falls to 30% for metastatic PCa.
In Denmark, with less screening than the U.K., overall 5-year survival is 69% [2].
With less screening, there are more advanced cases.
So, overall stats don't convey much.
14 years ago, when I was eager to discover my odds, there was an online tool where you could enter age, PSA & biopsy results, and get the 5-year rate per treatment option.
This was useful to me, but it's still a group rate. I believe that one can always do a bit better than than the group one is in. & for me, supplements have been part of my strategy.
-Patrick
[1] cancerresearchuk.org/health...
[2] eurocare.it/LinkClick.aspx?...
Interesting....the 5 year survival rate in the one study between 2002-2006 was 30%....Thanks for the post, Patrick...
I have Mets and my doctor said at the start I had a 50/50 chance of 5 years. That was 29 months, Mets are no worse But no better. Good luck guys with this monster.🙏🙏🙏🙏
Can anyone please help explaining to me what do I call myself at this stage in terms of the disease progress. Is it called advance pc? Metastatic advance pc? They found 6 mm lesion on T6 but they are not sure if it’s mets or not
good point - all I was told is I have regional PCa ---- no mets 2 yrs ago...
Are you still regional,?? If so---take a breath...the 5 year survival rate is like 95%...Good luck, ken...Have a good evening, brother
I guess that lesion will decide how to describe your condition.. I am Stage 4 with distant metastasis...my MO said 5-10 years, who knows... some people have been on zytiga and Lupron for more than 6 years and still doing well...I made comments about the one stampede study....5 years 7 months and nearly 30% had not failed treatment...if the lesion is not a met, and they think it is still in your prostate bed--localized disease... prognosis much better than mine....
I'ts a Guessing Game.
I went to see my favorite gypsy fortune teller and I knocked on her door, she said "Who is it?" So, I left....
Good Luck, Good Health and Good Humor.
j-o-h-n Monday 01/28/2019 7:53 PM EST
Fabulous....
when the numbers came out it was for women not men.
Chuck has been on Xtandi for 61 months. When Xtandi started failing, he was put back on Lupron, together with Xtandi. His PSA dropped to 0.1 and has stayed there for the past 49 months.
Selection Bias - Extrapolating Survival Times from posters
Survival rates for having PCa and bone metastasis???
Good News Story from Australia: Apalutamide to become available on PBS for men living with mHSPC
