Discovery of what spreads bone mets in prostate cancer??

[hillndale]

knowridge.com/2019/01/scien...

[pjoshea13]

There was a short thread on this a while back. Maybe you will stir up more interest.

healthunlocked.com/advanced...

-Patrick

[kaptank in reply to pjoshea13]

I think it ended in impasse on the question of what alternatives there are to Clogyline (the antidepressant monoamine oxidase A inhibitor). On the basis of similar modes of action, they seem to be deprenyl, pargyline and J-508.

researchgate.net/publicatio...

I can find no human trials. OK its an old and cheap drug, we know the story. But I would be interested to know if there is any new info that it might be a bad idea and a deal breaker to what looks on the surface like a no-brainer for human trial. After all, most APCa patients are depressed, some are being treated for it.

[Captain_Dave]

I may have posted this before, but will post again. There are a lot of foods and natural supplements that are MAO-A and MAO-B inhibitors (according to the article we should be looking at the MOA-A inhibitors). Some of the foods are things we eat and supplements are things many of us take. For example: Coffee, Carrot, Quercetin, Fennel, Ginger, Berberine, Parsley, Red Grapes, Curcumin

Here is a link to the article of foods and supplements:

botanical-online.com/englis...

Hope this helps,

Captain Dave

[kaptank in reply to Captain_Dave]

thanks. Very useful. I have found that Clogyline was never put into pharmaceutical production. (still available as a research agent). It had a side effect called the cheese effect. Eat cheese and it messes the tyrosine metabolism.