Is anyone familiar with glutamine and prostate cancer metabolic tumor growth?
I am vegan and I eat everyday humus and peans which are very rich in glutamine. I just found this info by accident and I sort of panicked because that is mostly the main source of protein I get on a daily basis. Any thoughts or experiences on this subject please?
Glutamine transporters are upregulated in some advanced PCa cells. The cells have a greater need for glutamine.
Glutamine can be a conditionally essential amino acid, but I doubt that one can easily create a deficiency. The body is usually able to synthesize what it needs. True, depending on tumor burden, advanced PCa might create a need for dietary glutamine - I don't know.
From 1990 [1] - Is Glutamine a Conditionally Essential Amino Acid?
"The nonessential amino acid glutamine has recently been the focus of extensive scientific interest because of its importance in cell and tissue cultures and its physiologic role in animals and humans. Glutamine appears to be a unique amino acid, serving as a preferred respiratory fuel for rapidly proliferating cells, such as enterocytes and lymphocytes; a regulator of acid-base balance through the production of urinary ammonia; a carrier of nitrogen between tissues; and an important precursor of nucleic acids, nucleotides, amino sugars, and proteins. Abundant evidence suggests that glutamine may become a “conditionally essential” amino acid in the critically ill. During stress the body's requirements for glutamine appear to exceed the individual's ability to produce sufficient amounts of this amino acid. Provision of supplemental glutamine in specialized enteral or parenteral feeding may enhance nutritional management and augment recovery of the seriously ill while minimizing hospital stay."
It's not clear to me whether you might benefit by restricting glutamine intake. I doubt it.
-Patrick
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