question regarding switching drugs....,

[DSEE]

Has anyone on this forum that has been taken off Zytiga that failed waited as much as 45 days to start another therapy with rising PSA?

Thankful for any response....

[Tall_Allen]

You can try switching from prednisone to dexamethasone first.

[DSEE in reply to Tall_Allen]

No I am already off Zytiga since 10-15.

MO dragging feet on starting any new drugs is why I am asking.

Don’t like being off treatment this long.

Asking how long others have been off treatment before starting another.

[Flash64 in reply to Tall_Allen]

Hi,

I'm assuming there is some positive outcome to switching to Dexamethasone. Is there any reference material that you know of that discusses the benefits? Thanks.

[Tall_Allen in reply to Flash64]

Sure:

onlinelibrary.wiley.com/doi...

[Flash64 in reply to Tall_Allen]

Thank you!

[tango65]

The timing and sequence of different therapies after one drug fails have not been defined by any control study as far as I know. Some doctors may wait to see progression of the disease before starting a new drug. If you are umconfortable with the approach of your MO you should seek a second opinion.

[DSEE in reply to tango65]

Thank you for your advise.

[tango65 in reply to DSEE]

Best of luck. I am in simlar situation (different medications) and I am getting a second opinion this week.

[DSEE in reply to tango65]

I am headed for second opinion on 12-04.

What was your original diagnosis ? - could not see your profile. Gleason?

Stage?

[Hidden]

Dave was taken off Zytiga after 3 months earlier this year and was given Xtandi instead without a break , which seems to be working well for him .

He was first diagnosed T4 N1 M1 in May 2017 , and has had Docetaxel and Radiotherapy.

[Willieboy]

I’m just coming off Zytiga in December, not sure what’s next. I hope it doesn’t take that long to find another treatment

[Mathes72]

I was off prednisone an zytiga one week,started jevtana