My husband has stage 4,psa was 420 now 11 after 1 hormone shot,flomax and 30 days of aberaterone. Now dr wants him on zytiga and Prednisone.

[Trisha65]

Is this best?

[joancarles]

It is a very good result. Going down is always great news. This means that the medication is working. I have 1 year of experience in Abiraterona.

Here you will find people who are very prepared and knowledgeable.

[Fairwind]

Abiraterone and Zytiga are the same drug..Abiraterone is the generic name. The combination of Lupron and Zytiga can produce a dramatic response as you have seen. has he had any scans to detect any possible metastasis ? At diagnosis, what was his Gleason score?

[Tall_Allen]

That's a great response for just 30 days!

[Hidden]

Probably!

[TommyTV]

I had a similar response, went from 571 to immeasurable in 12 weeks. Still doing well after 7 years😀

Zytiga, Prednisone and Zoladex (or Lupron) has achieved great results for many men.

[leo2634]

I've been on Zytiga Prednisone going in 10 months now PSA has been undetectable since first months treatments. I also receive six month Eligard injection. I just had CT scans and bone scan M O says he couldn't be happier with my results. All of my side effects have gone away except ED Which from what I understand is here to stay . I also stay active walking and riding my bike I would love to hit the gym as some of my Brothers on this site do God bless them but I'm happy with the results I'm experiencing this far. Never give up never surrender. Leo

[jdm3 in reply to leo2634]

Good news! What do they do for the bone scan in addition to CT?

[leo2634 in reply to jdm3]

I also have bone Mets that need to be monitored along with PC they have also subsided.

[jdm3 in reply to leo2634]

My question is more directed to how they monitor the bone mets. I'm trying to understand if it's just CT or they do a different scan too. Nuclear bone scan? My understanding is that a CT cannot differentiate between a malignant/dormant lesion and sclerosis or scar tissue from a dead lesion. All they can say for sure is that it is not getting bigger, which in itself is good, but for those who have radiation and ADT, a CT alone will not determine if the lesion/scar is not growing because of successful radiation or the ADT or both.

In my case, the rad onc said "CT scans cannot definitively distinguish between tumor and scar tissue, but seeing stable size of the lesion over time gives us confidence that there is no active tumor present. This is further supported by low/undetectable PSA. It is also true that even if we know that the tumor is controlled, we are not able to say whether it is due to SBRT treatment or ADT. We will only know that after ADT is stopped and your testosterone rebounds."

[tallguy2 in reply to leo2634]

My bone scan is 100% clean...as is my October 2018 MRI. But the PET scan with Axumin shows continued mets in the spine and lymph nodes. Don't just rely on the bone scan or MRI.

[leo2634]

It was a nuclear bone scan.

[jdm3 in reply to leo2634]

Thanks. Stay well.