Rib Fractures Mimicking Bone Metastases in 18F-PSMA-1007 PET/CT for Prostate Cancer.

[pjoshea13]

New paper below. Anecdotal case, but a warning that imaging reports can be flawed.

-Patrick

ncbi.nlm.nih.gov/pubmed/303...

Clin Nucl Med. 2018 Oct 27. doi: 10.1097/RLU.0000000000002354. [Epub ahead of print]

Rib Fractures Mimicking Bone Metastases in 18F-PSMA-1007 PET/CT for Prostate Cancer.

Panagiotidis E1, Paschali A, Giannoula E, Chatzipavlidou V.

Author information

1

From the PET/CT Department, Nuclear Medicine, Oncology Center, Theageneio Hospital, Thessaloniki, Greece.

Abstract

Prostate-specific membrane antigen (PSMA) is a membrane glycoprotein that is overexpressed in prostate cancer cells. It is also expressed in other normal tissues and several other malignant and benign diseases. We present a case of a 69-year-old man with history of prostate adenocarcinoma who underwent F-PSMA-1007 PET/CT due to suspected biochemical recurrence. PET/CT showed F-PSMA-1007 uptake in healing rib fractures with no other pathologic findings. Clinicians reporting F-PSMA-1007 PET/CT should be aware of this potential pitfall, especially in nontypical trauma pattern (eg, solitary osseous lesion) mimicking bone metastases.

PMID: 30371591 DOI: 10.1097/RLU.0000000000002354

[cesanon]

Patrick

This is very interesting.

Do you know what is the current US status of

18F-PSMA-1007 PET/CT scans?

One of the advantages of 1007 I like a lot is that it removes the risk of renal damage that the other psma scans present.

[pjoshea13 in reply to cesanon]

I don't know. -Patrick

[Scruffybut1]

Reasonably common as scans improve and existing breaks and cracks become confused. I am but one example!