I found this encouraging -Sept 2018- New cancer vaccine is 100 percent successful in mouse model - anti PD-L1 [Keytruda ?] plus Diprovocim

[George71]

Scientists have developed a new vaccine that — in conjunction with existing therapies — can not only treat aggressive melanoma, but also prevent its recurrence. It worked in 54 days.

medicalnewstoday.com/articl...

[pjoshea13]

pnas.org/content/115/37/E8698

[George71 in reply to pjoshea13]

thanks for the link

[dbrooks_h in reply to pjoshea13]

What is your thinking on taking anti-inflammatories in supplemental form vs nsaids.

Thanks for all the research you post here!

[pjoshea13 in reply to dbrooks_h]

The NSAIDs tend to have issues. One doesn't hear of such issues with polyphenols. An exception is tea extracts which have been known to be liver irritants for years. I take a mix of polyphenols at a combined dose that is pro-oxidant, because I want to induce ROS in the cancer cells. The bonus is that they are all NF-kB inhibitors. Chronically activated NF-kB is the source of the COX/LOX enzymes that act on arachidonic acid in PCa cells to produce inflammatory metabolites.

The list is long, but includes:

-curcumin

-resveratrol

-fisitin

-quercetin

-silibinin

-apigenin

etc, etc

I have posted on all of the polyphenols that have PCa papers on PubMed.

-Patrick

[dbrooks_h in reply to pjoshea13]

Great, I am new at this, so please bear with me, on PubMed what do I look under to see all your polyphenols post, and when you say pro-oxidant that is the opposite of antioxidants, thanks for your research and patiences.

[pjoshea13 in reply to dbrooks_h]

All of the polyphenols are antioxidants when used in moderation, as found in the diet. But at high doses, they become pro-oxidant. This is beneficial when trying to kill cancer cells. Most cancer treatments involve the generation of reactive oxygen species [ROS].

Frankly, I have yet to master the HealthUnlocked Search feature. Sometimes I have better luck with Google. Either way, search on <pjoshea13 "Foods/Supplements-Vitamins">. For a specific polyphenol, add the name to the search. Good luck!

-Patrick

[Fairwind]

The mice luck out again........

[j-o-h-n in reply to Fairwind]

aahhhhhh Rats!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/29/2018 9:53 PM EDT

[George71]

all approved meds have to be cleared by the rats first !