PARP Inhibitors Galahad Trial

[Hazard]

Since I became chemo-resistant in May this year, and failed to have any response at all to Xtandi, I had blood drawn for prescreening for Galahad trial a few weeks ago (they extract CTC from blood rather than doing an invasive tumour biopsy).

anzctr.org.au/Trial/Registr...

I got back test results yesterday - somatic DNA tested positive to BRCA2 mutation. I will now move onto the main trial. I need to have CT and bone scans to set baseline and then can start taking Niraparib. Hopefully within next 2 weeks.

PTEN mutation was not tested as this trial is restricted to PARP inhibitors. My post-RP biopsy in 2015 showed 5% intraductal PCA and with aggressive growth of cancer since then I assume that I have lost PTEN expression but that is a problem for another day.

Anybody else on Galahad trial, or tried Niraparib? How did it go, and what (if any) side effects did you encounter?

Ever onwards!

[Tall_Allen]

They just presented early results from a similar trial TRITON 2 at the ESMO conference. A similar PARP inhibitor (rucaparib) shrank tumors in about half of the men with somatic or germline BRCA1/2 mutations.

ir.clovisoncology.com/inves...

Here are the details (you'll have to blow it up to read it):

clovisoncology.com/media/11...

And here is an analysis showing how well the CTC analysis conformed to actual tumor tissue:

clovisoncology.com/media/11...

[paulofaus]

Good luck, I hope you respond!

[j-o-h-n]

Remember God is on your side.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 10/24/2018 5:38 PM EDT