Since I became chemo-resistant in May this year, and failed to have any response at all to Xtandi, I had blood drawn for prescreening for Galahad trial a few weeks ago (they extract CTC from blood rather than doing an invasive tumour biopsy).
I got back test results yesterday - somatic DNA tested positive to BRCA2 mutation. I will now move onto the main trial. I need to have CT and bone scans to set baseline and then can start taking Niraparib. Hopefully within next 2 weeks.
PTEN mutation was not tested as this trial is restricted to PARP inhibitors. My post-RP biopsy in 2015 showed 5% intraductal PCA and with aggressive growth of cancer since then I assume that I have lost PTEN expression but that is a problem for another day.
Anybody else on Galahad trial, or tried Niraparib? How did it go, and what (if any) side effects did you encounter?