A very good new. FYI

[Rilu]

lavanguardia.com/vida/20180...

Good morning dears,

Do you know this medication?

they want to try it on the PC

[Rilu]

Ibrance (Pfizer)

[Rilu]

clinicaltrials.gov/ct2/show...

[joancarles]

This news is from my country. I've heard about this man. I will try to find more information and publish it.

[podsart]

Ok but the link opens to Spanish language version -is there an English translation?

[Hidden in reply to podsart]

use google translate

[Rilu in reply to podsart]

That science advances by leaps and bounds is one of those phrases that, who more than least, has heard on occasion. Yes, it is a kind of topic, but not by topic it is not true. Màrius Soler (Barcelona, ​​1974) can give a good account of it. Not even half a year ago, this father of three children saw the future of a grayish color (it would not be fair to say black because an optimist does not beat anyone): Stage IV metastatic breast cancer (the most advanced) that was detected in 2017 did not give him a moment of respite. But a new treatment that began more than four months ago at the Hospital Clínic has returned the smile. "To be evicted, with a life expectancy of three years, to see salvation", tells La Vanguardia.

That science advances by leaps and bounds is one of those phrases that, who more than least, has heard on occasion. Yes, it is a kind of topic, but not by topic it is not true. Màrius Soler (Barcelona, ​​1974) can give a good account of it. Not even half a year ago, this father of three children saw the future of a grayish color (it would not be fair to say black because an optimist does not beat anyone): Stage IV metastatic breast cancer (the most advanced) that was detected in 2017 did not give him a moment of respite. But a new treatment that began more than four months ago at the Hospital Clínic has returned the smile. "To be evicted, with a life expectancy of three years, to see salvation", tells La Vanguardia.

Dr. Esther Zamora, from the Hospital de Barcelona, ​​knows first hand the way of the cross she has gone through. Not in vain, it is she who has been treating him from the first moment. He knows better than anyone the ravages that the disease has caused on his body in the form of bone injuries. "I have entered the operating room three times saying goodbye to my wife," recalls Màrius, "I did not know if he would leave, and if he did, he did not know in what situation he would do it: I could become paralyzed or quadriplegic".

After administering the second line of chemotherapy, Dr. Zamora was clear that she had to find another alternative for her patient. "He had a lot of pain in his back and legs, and also in one of the arms, because he has an injury to the humerus of his left arm." At that time he was "treated with radiotherapy to better control the symptoms." That's when the Hospital Clinic option appeared.

There is a drug, approved this year, which is giving very good results in the treatment of breast cancer and which is being applied, among other centers, at the Clínic. "That's why we derive it to this public hospital of reference, because these treatments can only be done through public roads," says Zamora. The problem is that this medication is indicated only for women (for every 100 cases of female breast cancer, there is a male one), and that is where the challenge lies.

At the Clinic they valued their case and decided to try it. "We had doubts, we played a little, but we had no alternatives," says Aleix Prat, head of oncology at the center. "In other hospitals it would not have been done because the evidence only exists in women, but here we made the bet and it went well," he adds.

The state of health presented by Màrius upon arrival at the center was an incentive for doctors to test the drug with him. "I was in a very delicate situation: physically touched, with an advanced cancer, with pain, I had spent other therapeutic actions ... It was at a point where, or we found something that worked, or in a few months we would have faced a situation really complicated, very limited and close to entering a very irreversible phase, "says Prat.

So they decided to start the treatment, and the results, surprising, did not wait: "After 15 days, the lump of the breast began to wane considerably," recalls Màrius. Seeing the incredible evolution, the doctors even told him that he could announce to his children that "the cancer was subsiding".

They say a picture is worth a thousand words. Well in the case of Màrius there are two, specifically two imaging tests (PET TAC), separated in time by just over four months, which attest to the incredible effect that treatment is achieving. "He has had an almost complete, excellent response," says Dr. Maria Vidal, oncologist at the Clínic. "It's amazing," adds Prat.

For physicians, more than the effect of the drug-it works on one in two women-what is really surprising is the speed with which it has acted: "It has been very fast and with a great improvement in the associated symptomatology".

The molecule that has worked the miracle responds to the name of palbociclib (marketed by the pharmaceutical Pfizer under the name of Ibrance). "It is a drug, which we call inhibitor of cyclins, and directed to act against the cell cycle, which is the machinery used by the cell to divide," explains Dr. Prat.

The results that this drug is reaping are so hopeful that, at present, it is being evaluated for other types of cancer, such as prostate or lung cancer. "But there is still no efficacy data," says Prat.

[Rilu in reply to podsart]

The drug is Ibrance (Pfizer).

In Canada, a clinical trial is under way with this drug for prostate cancer that will end in 2019

[Rilu]

no, I'm sorry, it's an spanish newspaper.

Este es el caso de un hombre con cáncer de mama, ya con una enfermedad terminal, sin posibilidad, a quien se le ha dado un medicamento que se usa solo en mujeres y en etapas más leves. Él ha tenido una remisión casi total y ahora el hospital español planea aplicarlo a otros cánceres, como el cáncer de próstata. A continuación publiqué el nombre del medicamento y un ensayo clínico sobre cáncer de próstata que se está llevando a cabo en Canadá y que está programado para finalizar en 2019 (en inglés).

[j-o-h-n]

TRANSLATION FROM ABOVE (spanish by RILU english by google translate). <====<<<

This is the case of a man with breast cancer, already with a terminal illness, without possibility, who has been given a medication that is used only in women and in milder stages. He has had an almost total remission and now the Spanish hospital plans to apply it to other cancers, such as prostate cancer. Then I published the name of the drug and a clinical trial on prostate cancer that is being carried out in Canada and is scheduled to end in 2019 (in English).

Good Luck and Good Health.

j-o-h-n Friday 09/28/2018 5:32 PM RDT

[Noel91]

Just Read this! Really interesting,I Will ask doctor about this!