eFFECTOR

[Magnus1964]

Has anyone had any experience with eFFECTOR? My drug trial with Xtandi is coming to a close and my research doctor says this could be the next step.

[docbulldog]

I am do familiar with eFFECTOR but am finishing my first year with Xtandi. I was hoping for positive results on this plan but my PSA has started to rise to the point my Dr will probably start me on a new plan. On Xtandi my PSA dropped to .17 but has gradually risen to .92, what is next I'm not sure but will find out the 15th of next month. Probably Zytiga and Prednisone plus continued ADT and Xgeva. I will have a hard time affording this new change, any suggestions will help.

[Magnus1964 in reply to docbulldog]

A PSA of .92 is still pretty low. Even if you are coming to an end with Xtandi your PSA will probably start bouncing around. I have been on Xtandi for 2 1/2 years and that is what is happening to me. I PSA goes up 2 points then comes down one.

I have found over the years that every ADT drug work in a different way and each has worked for a number of years. So if Xtandi really stops working, you have a choice of number drugs. I started out with Casodex, then went on to nilandren, Flultimide, then Zytiga and prednisone, and now Xtandi.

As to affording your drugs, ask your doctor to look into the Patient Access Network and Xtandi Support Solutions. These organizations can help you pay for your drugs if you qualify. If I can answer any questions on any of this let me know.

[ctarleton in reply to Magnus1964]

Another anecdotal perspective.....

I've done Lupron, brief Casodex, (Zometa), Provenge, and added Xtandi.

I've been on Xtandi for 2 years and 4 months, after original PSA 5 1/2 years ago did a roller coaster from 5,006 to 1.0 to 95.0. Lots of bone mets. My Xtandi nadir PSA was only as low as 1.2. During the last year and a half it has slowly been creeping up. In recent months, it has been bouncing around 2.9, give or take a tenth or two each time. My medical guys at UCSF are currently inclined not to even start talking about dropping Xtandi or doing other things until we see a rapid PSA trend, or values getting up into the 5-10 range or beyond.

Charles

[GeorgeGlass in reply to ctarleton]

why did you stop casodex?

[Magnus1964 in reply to GeorgeGlass]

The casodex was failing.

[Break60]

Must be a misspelling.Effexor is a drug for depression. Not a nice one though!

[Magnus1964 in reply to Break60]

See the following website: effector.com/

But on another note: see the following website concerning antidepressants and prostate cancer: nutritionreview.org/2017/03...

[Kevinski65]

I've heard about it. Don't know much about it. Where's the trial?

[Magnus1964 in reply to Kevinski65]

I am in Pennsylvania but I am not sure who or what institution is conducting the trial. It starts in October or November.

[BruceSF]

The drug is called tomivosertib - it is made by effector. Here’s a link to the trial announcement last December: effector.com/2018/12/11/eff...

It appears to do a good job on cancer cells that are resistant to zytiga or xtandi, but only in preclinical studies (Petri dishes and mouse models) do far.