4-MU Does it help?

[1950grammy]

Does 4-MU statistically lengthen life in advanced Prostate cancer?

[Tall_Allen]

It might if you're a mouse, but then, almost everything works in mice. There have been no human trials so far.

[1950grammy in reply to Tall_Allen]

You’re probably correct, unfortunately.

Thank you.

[Hazard in reply to Tall_Allen]

I wish I was a mouse. Friends often send me great news on PCa cures, just trying to help - and invariably it is a mouse study. My MO is not gonna give me anything based on a mouse study!!

[Hidden in reply to Hazard]

Lol. I understand your point Hazard; however, in reality, everything that you take, mice took before you. Then, they get sliced and diced.......

GD

[Captain_Dave]

Type "4-MU prostate cancer" in Google and see what comes up in the search.

[1950grammy in reply to Captain_Dave]

Positives and negatives. Thank you.

[milto27xabc]

I tried MU for 6 months----no effect on PSA so I stopped and haven't seen anything online since

[Magnus1964]

Try this article: academic.oup.com/jnci/artic...

The study showed that 4-MU has some benefit in preventing the metastasis of PCa.

[Tall_Allen in reply to Magnus1964]

in mice

[Hidden]

Whatcha sellin'?

[j-o-h-n in reply to Hidden]

This is a List of the Supplements I Take Daily

Best Adjuvants for Prostate Cancer

Medical Researcher & Writer

My background is that I was a very successful chemist who started several very successful businesses and now I am an older person with my own history of battling cancer and diabetes I have become focused on doing medical research and writing about what I find that may benefit some people. I created a website, maxlifespan, where I post the latest research I can find on supplements and breakthroughs in cancer, diabetes and other illnesses.

For example, 4-Methylumbelliferone (4-MU or Cantabiline) in one study 4-MU inhibited prostate cancer and bone metastasis in 100% of the animals in the study. Even after stopping treatment, no bone metastases developed. Used in Germany in 1930s to treat metastatic prostate cancer successfully. In recent declassified documents that were originally seized in Operation Paper Clip at the end of World War II, studies by German doctors on German Military Officers and prisoners in concentration camps showed a complete reversal of metastatic prostate cancer

TO ANSWER YOUR QUESTION I LOOKED BACK AT HIS POSTS (3 OF THEM) AND PASTED HIS FIRST ONE (ABOVE) WHICH HE DESCRIBES HIMSELF. yvw

Good Luck and Good Health.

j-o-h-n Sunday 05/06/2018 5:37 PM EDT

[Braunyny in reply to j-o-h-n]

A blast from the past ! Looks very interesting ! Do you have any recent data where this drug is being tested or used ? Thanks ,Brauny

[j-o-h-n in reply to Braunyny]

to Braunyny,

Sorry but I was merely posting what "maxlifespan" had posted, in answer to WSOPeddie question (see above).

Try directing your question(s) to Maxlifespan <====<<<

Good Luck and Good Health.

j-o-h-n Thursday 05/10/2018 11:13 AM EDT

[Prodius]

Max, was it the 4-MU that lowered you PSA a year after your prostate surgery? It seems like you were able to avoid radiation with the items you take. Could you post your supplier of 4-MU

[George71]

do you take doxy -- contentiously or for x days and then stop for x days?

[jdm3]

Do you have a reference to "Doxycycline is clinically approved in the U.S. to block bone cancer" ?. Thanks.

[johnscats]

i read your latest on this drug i have ordered from france when is the best time to take it with or without food i have stage 4 prostrate cancer am on firmagon and rso cannibiss oilhave had relly good results so far and am going to add this to my treatment hope you cure continues best of luck j

[JLS1]

ncbi.nlm.nih.gov/pubmed/258...

J Natl Cancer Inst. 2015 Apr 13;107(7). pii: djv085. doi: 10.1093/jnci/djv085. Print 2015 Jul.

Dietary supplement 4-methylumbelliferone: an effective chemopreventive and therapeutic agent for prostate cancer.

Yates TJ1, Lopez LE1, Lokeshwar SD1, Ortiz N1, Kallifatidis G1, Jordan A1, Hoye K1, Altman N1, Lokeshwar VB2.

Author information

Abstract

BACKGROUND:

Prevention and treatment of advanced prostate cancer (PCa) by a nontoxic agent can improve outcome, while maintaining quality of life. 4-methylumbelliferone (4-MU) is a dietary supplement that inhibits hyaluronic acid (HA) synthesis. We evaluated the chemopreventive and therapeutic efficacy and mechanism of action of 4-MU.

METHODS:

TRAMP mice (7-28 per group) were gavaged with 4-MU (450mg/kg/day) in a stage-specific treatment design (8-28, 12-28, 22-28 weeks). Efficacy of 4-MU (200-450mg/kg/day) was also evaluated in the PC3-ML/Luc(+) intracardiac injection and DU145 subcutaneous models. PCa cells and tissues were analyzed for HA and Phosphoinositide 3-kinase (PI-3K)/Akt signaling and apoptosis effectors. HA add-back and myristoylated Akt (mAkt) overexpression studies evaluated the mechanism of action of 4-MU. Data were analyzed with one-way analysis of variance and unpaired t test or Tukey's multiple comparison test. All statistical tests were two-sided.

RESULTS:

While vehicle-treated transgenic adenocarcinoma of the prostate (TRAMP) mice developed prostate tumors and metastases at 28 weeks, both were abrogated in treatment groups, without serum/organ toxicity or weight loss; no tumors developed at one year, even after stopping the treatment at 28 weeks. 4-MU did not alter the transgene or neuroendocrine marker expression but downregulated HA levels. However, 4-MU decreased microvessel density and proliferative index (P < .0001,). 4-MU completely prevented/inhibited skeletal metastasis in the PC3-ML/Luc(+) model and DU145-tumor growth (85-90% inhibition, P = .002). 4-MU also statistically significantly downregulated HA receptors, PI-3K/CD44 complex and activity, Akt signaling, and β-catenin levels/activation, but upregulated GSK-3 function, E-cadherin, and apoptosis effectors (P < .001); HA addition or mAkt overexpression rescued these effects.

CONCLUSION:

4-MU is an effective nontoxic, oral chemopreventive, and therapeutic agent that targets PCa development, growth, and metastasis by abrogating HA signaling.

© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: [e-mail].

PMID:

25868577

PMCID:

PMC4554252

DOI:

10.1093/jnci/djv085

[Indexed for MEDLINE]

Free PMC Article