My dad is 71 yo, stage IV, mets to sacrum, one rib and shoulder. He’s done basically every approved treatment. Showed good progress on Xtandi for 9 months then just one good month on Xtandi.
If we were able to get Daralutamide or Proxilutamide, would we see any results?
Neither of those are available outside of clinical trials, and we don't yet have proof that either is better than what he has tried. Unless he has failed Jevtana, he can try it again and rechallenge with Xtandi afterwards. Estrogen patches may still work, if he hasn't tried that yet.
Failed Jevtana.
His oncologist is willing to administer Daralutamide under Right to Try.
Real good chance Darolutamide will work....different chemical structure than Xtandi and works on mutated AR's
Gus
Dam,
Is that a State Right To Try Law....if you can keep us posted...your Dad would be the first guy here to try Darolutamide...I hope it works for years
Gus
Has he tried Zytiga? I have been on Lupron since diagnosis in 2015 at age 53 (stage 4, Gleason 8). PSA went from 227 to undetectable in 3-months. Remained undetectable for a year and then slowly crept up to 1.8. In December 2017, I started Zytiga + Prednisone and within a month back down to undetectable. Working well and few side effects.
Hope this helps. Best of luck! Our thoughts and prayers are with you and your dad!
James
Yep, tried Zytiga after Xtandi with no real results.
Sorry - But I’m sure someone here will have some very good suggestions! Don’t lose hope!
James
Has he tried Provenge or Radium 223?
He did Provenge forever ago. 5 Radium 223 shots.
Please let us know, how things go with the right to try procedure, much appreciated. If one can get darolutamide early, I think it is worth a try.
Good Saturday Morning Damusolf,
I assume he has already had Docetaxel chemo?
Please see my post yesterday about rechallenge with Xtandi. My cancer is responding to Xtandi after failing it in 2015-2016, evidently having been sensitized from chemo.
Best wishes. Never Give In.
Mark, Atlanta
Hi, My husband Sam is also stage IV, we just recently qualified finically for a drug called cometria. It's a targeted therapy drug. I'm praying and fingers crossed. Sam started his journey at age 65, he is now 74 young...
I did read an articial about proxelutamide and one called baroultamide. The head line read: Death from cancer might be over!!! Wouldn't that be wonderful!!! I pray for that everyday!!!! Please let me and the rest if you are able to get the drug. Do you know if the drug proxelutamide is a targeted therapy drug???
Prayers for you and your Dad....🙏🏻
Love, LynnPa.
Here's some info about the Right to Try law for those interested. cnn.com/2018/03/22/health/f...
Check out LU177 which is in clinical trial at UCLA and Excel in Houston. Also might benefit from spot radiation (preferable proton) to get rid of the known liaisons.
I would contact the National Institutes of Health/National Cancer Institute. that is the federal government medical research facility. within the NCI page is a search engine where you put in your age, disease and zip code and it gives you a list of clinical studies and trials at NIH and at NIH approved facilities within 100 miles of where you live.
I advise you to contact Prof Henry Lai at the university of Washington directly. I used Artemether in the form of Coartem to clear up my mets. Gone.
Abiraterone failing...Xtandi next best step? 
What comes after, what comes next? 
Failed Docetaxel, then Xtandi, what next?
What next after chemo?
What to do next for treatment
