Looks Like Metformin - Resveratrol - ... - Advanced Prostate...

Advanced Prostate Cancer

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Looks Like Metformin - Resveratrol - Ursolic Acid - Curcumin Is The Best Combo to take With Xtandi or Zytiga

gusgold
gusgold

May prevent resistance from developing to X or Z. Ursolic acid is poorly absorbed and can be dangerous. I found a standarized 10x Apple Peel Extract from Maple Life Sciences called Green Apple 10:1 on eBay...ships from India but only took about 10 days to receive.

Gus

nature.com/articles/s41698-...

22 Replies
oldestnewest

Eat Rosemary and Thyme, Elderberries, Prunes--it use to be in a high amount in the old Zyflamend--and it is in BIRM. I think you have now passed me in the amount of supplements you are using.

Nalakrats

BigRich
BigRich in reply to Nalakrats

Rosemary and Thyme spices do you sprinkle on your food or do you add it to your stew or fish or chicken breast? Are frozen elderberries or canned as good as freshly picked?

Rich

PS: Prunes have too much sugar for me, I am a diabetic.

Nalakrats
Nalakrats in reply to BigRich

Anyway you can get them---I grow them fresh---and go out and snip them and add to food cooking.

Nalakrats

podsart
podsart in reply to Nalakrats

What about oregano as well as a source?

Nalakrats
Nalakrats in reply to podsart

Probably some?

Nalakrats

podsart
podsart in reply to Nalakrats

This says cranberries:

J Sci Food Agric. 2011 Mar 30;91(5):789-96. doi: 10.1002/jsfa.4330. Epub 2011 Feb 23.

Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells.

Kondo M1, MacKinnon SL, Craft CC, Matchett MD, Hurta RA, Neto CC.

Author information

Abstract

BACKGROUND:

Ursolic acid and its cis- and trans-3-O-p-hydroxycinnamoyl esters have been identified as constituents of American cranberries (Vaccinium macrocarpon), which inhibit tumor cell proliferation. Since the compounds may contribute to berry anticancer properties, their content in cranberries, selected cranberry products, and three other Vaccinium species (V. oxycoccus, V. vitis-idaea and V. angustifolium) was determined by liquid chromatography-mass spectroscopy. The ability of these compounds to inhibit growth in a panel of tumor cell lines and inhibit matrix metalloproteinase (MMP) activity associated with tumor invasion and metastasis was determined in DU145 prostate tumor cells.

RESULTS:

The highest content of ursolic acid and esters was found in V. macrocarpon berries (0.460-1.090 g ursolic acid and 0.040-0.160 g each ester kg(-1) fresh weight). V. vitis-idaea and V. angustifolium contained ursolic acid (0.230-0.260 g kg(-1) ), but the esters were not detected. V. oxycoccus was lowest (0.129 g ursolic acid and esters per kg). Ursolic acid content was highest in cranberry products prepared from whole fruit. Ursolic acid and its esters inhibited tumor cell growth at micromolar concentrations, and inhibited MMP-2 and MMP-9 activity at concentrations below those previously reported for cranberry polyphenolics.

CONCLUSION:

Cranberries (V. macrocarpon) were the best source of ursolic acid and its esters among the fruit and products tested. These compounds may limit prostate carcinogenesis through matrix metalloproteinase inhibition.

Copyright © 2011 Society of Chemical Industry.

If true what about this NOW cranberry concentrate 1400mg just cranberry?product?

J Sci Food Agric. 2011 Mar 30;91(5):789-96. doi: 10.1002/jsfa.4330. Epub 2011 Feb 23.

Ursolic acid and its esters: occurrence in cranberries and other Vaccinium

If true, how about NOWs cranberry concentrate (1400mg just cranberry)?

Any downsides?

Nalakrats
Nalakrats in reply to podsart

I forgot about cranberries---they were on a list--and was writing from memory---

Thanks

Nalakrats

gusgold
gusgold in reply to Nalakrats

Amazon has Pure Company cranberry concentrate 50:1

Nalakrats
Nalakrats in reply to gusgold

It is tough to drink--but if you mix it with Gator Blood, and throw in some Yew and throw in some THC, DMSO, and also EMU oil, with a touch of DMT---you will kill something!

Nalakrats

podsart
podsart in reply to Nalakrats

Of course this now raises the issue we just dealt with, quality control of supplier-in this case NOW-which seems to be one of the more reliable manufacturers, or do we need to do some sort of analysis to validate this assertion?

Also, how do we determine how much product to take to reach the supposedly optimal blood levels ? In this case, each dose is labeled 1400mg , but I know Dr. Myers would routinely determine a dose usually higher than the label. Is there an absorbing calculation , or do you just guess with the label dose ?

podsart
podsart in reply to podsart

And possible interaction with the many other items you are taking

Nalakrats
Nalakrats in reply to podsart

The Label--is an average of many batches---dealing with a natural grown product always causes some up and down leeway.

Nalakrats

Myriammole
Myriammole in reply to Nalakrats

In Birm there is ursolic acid? so no need for extra supplement?

Nalakrats
Nalakrats in reply to Myriammole

It is not reported in the Patent, filed with the US Patent Office. You can use Holy Basil, that has CO2 extractives, for a good level of Ursolic acid.

Nalakrats

Myriammole
Myriammole in reply to Nalakrats

In the LE curcumin you mentioned holy basil as well but I don't find in the ingredients. Will check. Do you take any specific label?

Nalakrats
Nalakrats in reply to Myriammole

Gaia Herbs---> Holy Basil--their extraction facilities are just about 15 miles from me. I plan to visit, and do a tour---since I helped bring this technology from Europe in the 1980's I assume they would let me tour. Want to do it with Patrick---but cannot get a schedule yet. I have Co-Solvent Proprietary knowledge that they may or may not be employing--I have no idea--or I may be the one coming from the caveman age, and they have moved way past what I think I know. I trust them, as they grow their own Herbs on Hundreds of Acre's and process--on site.

Nalakrats

Hello! My hormonal treatment is Zytiga. My supplements are curcumin, green tea and pomegranate juice.

Actually, that's a pretty good combination for any PCa patient, whether or not they are taking Xtandi or Zytiga.

That article reported on the use of a rapid screening technique to identify the combination of reseveratrol, curcurmin, and ursolic acid. The history and literature on Metformin is very large, there's really no good reason that every single prostate cancer patient isn't prescribed it.

The main caveat is that they did this study in mice. They are very, very good at curing cancer in mice and rats. Humans, not so much.

That article was by far the prettiest article with the highest number of big words that I did not know, ever! Now, does anyone have anything written using terms that I can understand; that was not a study using rats or mice to illustrate the benefits of this combination of supplements?

FCoffey
FCoffey in reply to Don1157

If you want a study of supplements affecting prostate cancer in human trials, there is a discussion about Pectasol-C

healthunlocked.com/advanced....

There are other studies of supplements, but I don't know of any human trials with ursolic acid.

Here is a list of 49 clinical trials involving prostate cancer that included "dietary supplement" as part of the intervention.

clinicaltrials.gov/ct2/resu...

Does Metformin curcumin cause loose stool for anyone?

FCoffey
FCoffey in reply to George71

Some people report that. Myers cautions about it.

I haven't seen it. I get loose stool from time to time, but I've been taking metformin for years and do high-dose curcumin from time to time, and don't notice any strong correlation.

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