Advanced Prostate Cancer

Genome Testing

I had blood drawn last week to have it tested for busted genes. That's the best way I can put it. I got into a program with the Univ. of Penn and Virtua Health. I'm very excited about it, and what I/we will learn from the results.

The testing is being done at Embry Genomics, so I believe it's not a specific test, like Guardant. Is anyone else on the genome train?

Joe

UPDATE: 9/8/17

I had a BRACA 1 & 2, and a ProstateNext test. Just 14 suspicious genes are tested, as opposed to the Guardant360, which tests, I think, for 74 genes. Anyway, the test came back negative, good for my family, but still leaves me hanging. I must have got it, because I sleep in a prostate position. Yup, that's it.

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Should be interesting Joe. I had a decipher test done using a prostate sample after surgery. Basically told me I have an extremely high risk profile. Mixed bag knowing this. Great as I now will get the most aggressive treatment needed, bad in that I'm feeling sometimes like I'm a ticking time bomb. On a net basis good though.

Look forward to hearing more about your test - good luck

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Yes I had mine done by Foundation One about 8 months ago---we tested 340 Genes, and found 2 that have mutated, and already have targeted drugs that can be used against the mutated Genes. 2 drugs got approved in April. I am at a stage where thank GOD I do not need them, as I am still in a controlled state against my Pca.

Nalakrats

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What were your 2 genetic mutations Nal?

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BRCA-2 and PTEN--we have now 3 targeted drugs for BRCA-2. And one that has had some positive effects, against PTEN, but in only about 8% of the trial cases. More work continues on finding PARP inhibitors against PTEN, as this is a popular Gene for mutation.

Nalakrats

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According to Moores Cancer Center UC San Diego there are 4.3 million three drug combinations for cancer and each patient is unique. I'm a 14 year survivor who went through RP, androgen deprivation and radiation but if I was going through it today I would run, not walk, to a facility or company that would use genetic testing to assist in designing an optimal personalized treatment. Maybe would still do what I did but one size doesn't fit all and no oncologist can have knowledge of 4.3 million combinations. I don't want to sound like an advertisement but there are companies out there who will work with your oncologists, even remotely, to design a personalized unique therapy. Ask me if you'd like the names. They are not expensive.

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Yes please!!

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Hi Daddysdaughter,

I just happen to be on this page, what is it your looking for?

Joe

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New to all these treatment possibilities for my father. Should we start with Xtandi and see if it works or should I take my father for a consult for genetic testing?

Diagnosed 3 yrs ago

Gleason 9

Radical prostatectomy

10/12positive nodes

Radiation therapy

Lupron

In 2015-2016 PSA <0.01

In November of 2016 - august 2017 PSA increased to 3.7

PET Scan August 1st 2017

Mets to lymph nodes from iliac pelvic region nodes to chest nodes and cervical lymph nodes..

Plan is to start Xtandi when he returns from his European trip.

Any suggestions?

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I sure do daughter, have a huge welcome back party for your Dad. And, if he is strong, I would go the chemo route. Xtandi or Zytiga won't do anything for the lymph nodes. It's either radiate them, or chemo them. I think. There is a guy who just posted about how chemo took all his chest nodes away. I wish your Dad the best, and keep the crew here updated. You'll always find help.

Joe

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Joe, I had many lymph nodes greatly reduced on xtandi, and also zytiga. that's what they are supposed to do.

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Sorry Dan, I knew that.

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Personally I think that is a good option IMO, If it works you get more time, truthfully no one really knows what drugs will work in who, as we are all different .Lymph node positive is much better than showing a lot of bone mets, I have had both for 11 years, I think I would follow with more frequent psa test in the future, I hope he enjoys Europe, where in Europe will he be touring?

Dan

ps you can read my latest scans path reprt by clicking on my name and reading my last post

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I would like the names of the company's, please.

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I have as P53 repair gene deficit, and BRCA2 positive.

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Sorry, I am behind in replying. Call or write to CureMatch. If you contact them they will be sure to connect you with the right person. You can spend some time on the company's website also.

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I am 7 years into dealing with PCa. After failed Proton Therapy and failed Salvage Cryo, I decided to have a DNA test.

I used Color Genomics and the genes below were analyzed, and no pathogenic or likely pathogenic genetic variants

APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4*, CDKN2A (p14ARF),CDKN2A (p16INK4a), CHEK2, EPCAM*, GREM1*, MITF*, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, POLD1*, POLE*, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53

However, a pathogenic mutation was identified in the PMS2 gene.

Pathogenic mutations in the PMS2 gene cause Lynch syndrome. This is an inherited condition that increases the risk of developing certain cancers, including colorectal and others.

So, now I get to have a colonoscopy annually. Woopee!

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