PSADT

[Alinur]

PSADT<1month! from March till now PSA rose from 0 to 0.7.cancer found in pelvis bone(MRI).The spot was not there in January(very aggressive).Can this be the only source of this aggressive PSA Soar or more cancer is to be found!

RP in 2011,SRT+ ADT.No therapy since September 2016!

Thanks guys!

[ctarleton]

You might consider getting monthly PSA tests to keep a closer watch on your PSA trends and doubling times.

mskcc.org/nomograms/prostat...

You might also ask your doctor about if/when you might get another type of scan for further evaluation of your disease status. Names like NM Bone Scan, PSMA PET, C-11 Choline, F-18, Axumin, etc.

Some related overview info is here as a starting point for further research and discussion with your doctor, or referral to other specialists:

pcnrv.blogspot.com/2016/12/...

Finally, you might begin your own research by Googling the search term "oligometastatic prostate cancer"

google.com/search?q=oligome...

Charles

[Alinur in reply to ctarleton]

Charles,

I had 2week PSA since March and the trend was monthly doubling!Had MRIs which showed that 12mm acetabullum met.thanks for the sites.

[wifeofvet in reply to Alinur]

anyone ever suggest you have that spot radiated??? my husband has the most aggressive form...diagnosed with bone mets to ribs at the same time as prostate biopsy came back positive at age 57. he had major exposure to agent orange in Nam. his PSA went from zero to 1 to 77 in two six month interval tests before diagnosis, and then a gleason score of 10 at diagnosis. as mets popped up in shoulder and pelvis and long bones, they spot radiated to slow progression. he's failed every drug there is, and every chemo..and today is the 12th anniversary of diagnosis. his prognosis at diagnosis was a 1% chance of surviving three years.,,before abiraterone and enzalutamide came on the market.

arrangements are being made for him to take Xofigo next week. unfortunately, he's no candidate for clinical trials because he also suffers from Stage IV laryngeal cancer...the second most common cancer from agent orange exposure.

[Break60]

Fast psadt is definitely a troubling sign. I assume it happened after you stopped ADT . What was your PSA history since RP and what was your pathology? I've had a similar fast doubling time problem due to Gleason 9 and poor pathology. I've had 3 recurrences. In prostate bed, in pelvic lymph nodes found by MRI and in femur found by axumin ctpet scan. So I'm back on ADT, on xgeva and had SBRT to the bone met. PSA back down to .3 from 2.3. All I can say is that my PCa is systemic and I just need to keep fighting it systematically and focally. You're probably in a similar boat.

Bob

[Alinur in reply to Break60]

Bob,my Gleason was 3+4=7 & T3b. I never allowed PSA to exceed 1 during HT vacation.MRIs never showed anything.But this time at PSA=0.6 MRI found a suspicious area in the iliac bone.It was not there in my last MRI.PSA is now rising faster than other times!

I have severe Osteopenia and degenerative disease in almost all the skeleton.That is why bone scan is not reliable in my case.

I hope to have PETCT soon.

Bob, how did SBRT worked for you? Did it eliminate the met?

Thanks

[Break60 in reply to Alinur]

Alinur

I'm pt3b too but 4+5=9. You know that pt3b is not good. My PSA went to .3 after RP then I had SRT. It then went to 1.2 and I had MRI which found two hot iliac nodes so I had all pelvic nodes radiated with75 grays and 13 months ADT. Lastly afte stopping ADT I let PSA rise to 2.3 and had axumin scan and SBRT to single femur met. I don't know if the met is gone but I read that SBRT doesn't necessarily kill the cancer in bone but knocks the heck out if it. Since I went back on ADT it's hard to tell what caused PSA to decline to .3 but with my high risk PCa I can't take the chance of doing just focal treatment.

Bob