Anyone have a good run on both. They say they are cross resistant.
Zytiga to xtandi sequence: Anyone have... - Advanced Prostate...
Zytiga to xtandi sequence
![Drcrunch profile image](https://images.hu-production.be/avatars/2e54f497743c0ee4c37441eb72548fc3_small@2x_100x100.jpg)
![Drcrunch profile image](https://images.hu-production.be/avatars/2e54f497743c0ee4c37441eb72548fc3_small@2x_100x100.jpg)
I got about 18 months on Zytiga and 12 months on Xtandi. Had high dose ketoconazole in between. Now taking Lynparza, as Guardant360 liquid biopsy indicated an ATM defect. Will reach 5 year anniversary on August 6th. Not too bad, since I had a 25% chance of living 5 years with original diagnosis: PSA=29; Gleason=10; many lymph node mets. Never Give In! Thank you Dr. Charles "Snuffy" Myers. I will forever be grateful.
Vandy,
How I wish I had a concerned doctor, or at least one who could read anyway, when my travails began. So many men here have praised Dr. Myers in so many ways, it's dizzying. When I was DX, I went with the big boys on the block, thinking a larger group would be of benefit. That wasn't the case. I was told, and seconded, that I couldn't have an RP because it was in my lymph nodes. So, I was looking for my original biopsy grading to post on my profile here. I found Tb2 as my current grading. But, that can't be, it must be T2b N1, because I had lymph node involvement, right. So, I got in touch with the records department at my old Onc's office, and after about twenty minutes I had an answer. "Lymph node adjacent to seminal vesicule, questionable". On top of this, I was Dx with a bladder blockage some three years later, and no one told me nor did they treat it. It was agonizing in the end when it was finally discovered about 2 1/2 years later in the ER.
Believe when I tell you, I had THE worst care imaginable, but they were nice. lol
Joe
Yes - 18 months on zytiga, and now more than 42 months on xtandi. Pretty good control with zytiga, but suffered a PSA and lymph node relapse after 18 months, prompting a switch to xtandi, which has been great for me. Have had an undetectable PSA with no observable mets the entire time while on xtandi - I also did provenge, and added metformin and a statin while on xtandi, as well, which probably helps with control.
I had 5 years on Casodex, 3 1/2 years on Zytiga and now on xtandi for just over a year and still going.
Magnus,
Are you also on Lupron? Haven't you been fighting for 23 or 24 years?
Rich
No I have never received Lupron. I had an orchiectomy, Lupron work on the testacies. I have been fighting for 25 years. Everyone is different and drugs work differently on different people. All I can say is with a Gleason score of 9 and PSA of 39 the doctors gave me a grim outlook 25 years ago.
My advice to all is research all you can and take your healthcare in your own hands. I have fired a few doctors along the way and went through a lot of alternative therapies. I've been told that I have an aggressive cancer but is it has never acted like an aggressive caner. Is this due to the alternative therapies, or because I turn vegetarian after being diagnosed?
My sound advice is learn all you and do all you can for yourself.
well as I have mentioned before I took three years ago zytica for eight months then taxodere chemotherapy eight sessions and then JEVTANA fifteen sessions my PSA went up from the beginning slowly from 8 to 156 with no major side effects made 2 PT/CT scan and results showed on both location of the so called cancer. Four months ago I started taking an injection of decapeptyle 11.25 and xtandi PSA went down From 156 to 2.15 no major side effects. Hope you all get better.