PSADT at this level

[Alinur]

I am in ADTvacation.PSA Jump from 0.024 to 0.082 in 35 days.isn't that too rapid rise!

[AlanMeyer]

That does seem rapid, though the numbers may be deceiving. When we're dealing with microscopic amounts of PSA a very small number of extra molecules of PSA, possibly coming from variable sources, may make a large relative difference.

However, if this continues for another month then maybe your vacation should be over.

Some oncologists will offer Avodart to patients on an ADT vacation in an attempt to hold the growth of cancer down without the larger side effects of Lupron, Zoladex, etc. That may or may not help you but could be worth a try.

Alan

[Break60]

It is rapid and I had the same result: doubling monthly. I never stopped avodart when I went on vacation . My RO added finasteride but it did no good. So I'm back on Lupron and casodex and am exploring SBRT to a bone met found by axumin scan when PSA reached 2.3. I agree that you should get monthly tests and a F18 type CT PET scan like c11 choline or axumin when PSA gets between 1 and 2.

Bob

[eggraj8]

If the numbers were 0.24 and 0.82 then the answer would be yes. But you are an order of magnitude below that in an area where many of the tests previously considered the error region. If in the next month it goes up again to say over 0.10 then it is time to act.

[pjoshea13]

In the off-phase of IADT, testosterone [T] will rise. Sometimes quickly, often not. As T rises through the hypogonadal range, PSA will rise too. When T has reached Morgentaler's androgen receptor 'saturation' point, additional T should not have any effect on PSADT. (Dr. Myers has said as much.)

In other words, you can't start to measure PSADT until T has reached at least 250 ng/dL. (Myers was more conservative & said 350.)

It's a bit unnerving, but you can't see the trend in the first 35 days, & should not even include them - IMO.

As Alan suggests, Avodart would be a prudent precaution. My view is that estradiol [E2] should be considered too. Until T exits the hypogonadal range (<350 ng/dL), T will be permissive to E2-driven growth. So Arimidex + Avodart might extend the vacation. (For the adventurous, T replacement, to speed the transition to normal, would shrink exposure to estrogen dominance.)

Nalakrats might also say (& I agree) that DIM, to metabolize E2 down the 'benign' pathway would be prudent too.

In the absence of T, DHT & E2 test results, it's all guesswork.

-Patrick

[Hidden]

I went on a Lupron vacation 6 months ago. My PSA has remained at <0.006 and my T has risen from <3 to 12 (whoop de doo). I had been on Lupron since 2011.

I am continuing the remainder of my ADT regimen:

Nilutamide (75 mg/day), Dutasteride (0.5 mg every other day), Cabergoline (0.25 mg every other day), Metformin (500 mg/day).

If my PSA rises to 0.1 ng/ml then I will probably go back on Lupron if my oncologist agrees.

Clint

[Magnus1964]

I would wait for the next PSA test to make a judgment. If the next test show a tripling effect I would think its time to take some action with something else.

[Alinur]

Thank you guys! Got my other Tests:

FSH=37 V.high

LH=15.high

T=353

Iam hypogonadal because SRT damaged my testes.Idon't know how this high values of FSH &LH can play a Roll In PSA. Iam G7 and my PSA have never been over 1 .

[Hidden]

No. That's the problem with ultra sensitive assays. Your body will always produce PSA in minute levels. They cause unnecessary worry and panic. For example, my PSA is less than 0.1 and that is all I care about

GD