Metabolic Syndrome & Aggressive PCa at Diagnosis.

[pjoshea13]

New Italian study below.

Those who have followed my posts touching on the issue of MetS & PCa might be wondering why this kind of study would still be required in 2017.

PCa is usually described as a hormonal cancer, although there is no evidence that it is actually caused by normal levels of testosterone. The connection between PCa risk & CVD risk has long been recognized, but very few doctors would describe PCa as being part of a metabolic disorder.

"Links between metabolic syndrome and prostate cancer after androgen deprivation therapy are emerging." This is exasperating. Men on ADT - & their doctors - are well aware of the consequences (not side effects!) of ADT.

"The aim of the research was to investigate the association of metabolic syndrome and aggressive prostate malignancy, at initial diagnosis, without the influence of hormonal treatment.

"Metabolic syndrome was significantly associated with aggressive prostate cancer" Risk factor = 1.87.

"In our study, patients with metabolic syndrome were more likely to present with more aggressive prostate carcinoma vs. patients without metabolic syndrome."

Addressing MetS in new PCa cases might slow progression.

Regardless of biopsy results, MetS should be treated. This might be very important for men on active surveillance, where 25-30% are expected to progress.

{How many of our doctors read the Hormone and Metabolic Research journal, I wonder?}

-Patrick

ncbi.nlm.nih.gov/pubmed/284...

Horm Metab Res. 2017 May 11. doi: 10.1055/s-0043-109866. [Epub ahead of print]

Metabolic Syndrome and Aggressive Prostate Cancer at Initial Diagnosis.

Di Francesco S1, Tenaglia RL1.

Author information

Abstract

Links between metabolic syndrome and prostate cancer after androgen deprivation therapy are emerging. The aim of the research was to investigate the association of metabolic syndrome and aggressive prostate malignancy, at initial diagnosis, without the influence of hormonal treatment. Retrospective analysis of 133 patients with prostate tumor diagnosis between 2007 and 2009 was conducted. Patients with prostate cancer were subdivided in 2 groups according to Gleason score: Gleason score≥7 as high-grade prostate tumor (Group 1) and <7 (Group 2) as low-grade prostate tumor. Metabolic syndrome was defined according to International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute definition. Metabolic syndrome was significantly associated with aggressive prostate cancer (OR 1.87, p<0.05) and a reduced risk of low-grade prostate cancer (OR 0.53, p<0.05) at initial diagnosis, without the influence of endocrine therapy. In our study, patients with metabolic syndrome were more likely to present with more aggressive prostate carcinoma vs. patients without metabolic syndrome. Further research should elucidate these relations in larger samples to confirm these associations and to stabilize future prevention and therapeutic strategies.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID: 28494504 DOI: 10.1055/s-0043-109866

[BigRich]

Patrick,

It is a balancing act. I lost 100 lbs, another 30 to go to aid in fighting MetS. I brought down my AIc score to 5.8, for I am a diabetic. I did this without diabetic drugs.

The warning you give is to fight PCa we musht not overlook the MetS, for to keep death at bay we fight on all fronts.

Rich

[Scruffybut1 in reply to BigRich]

Rich I am living the same life. My PSA now 0.03, stable. Non fasting glucose between 12 & 21 h1b 17. So ca drugs have whacked me from average 5. Seems the drug hitting my diabetes hardest is Zytiga. It is also the one that has hit the PCa hardest. Double jeapardy! I lost 10kgs since Christmas Day but was 94 KGS then. Not a bad weight for me but more energy as I scale down towards 79kgs and I think more effect from my meds at the lighter me. Good luck. It's a real bummer of a balancing act.

[rococo in reply to BigRich]

I always was curious of what tbe effect of matabolizing your own body fat vs a high fat diet on psa, cvd, I HAVE BEEN ON diet for the past few months and psa has been going up while on 150 mg casodex and avodart which i'm going to switch to procar 2wks before next psa test. Any comments welcomed.

[BigRich in reply to rococo]

Rococo,

I had to switch from 150mg. Casodex to Lupron and 50mg. Casodez due to rising PSA while on Casodex.

Rich

[joeoconnell]

i wonder if only i do not understand this

[j-o-h-n in reply to joeoconnell]

Joe

Join the scratch your head and shrug your shoulder's club. I'm the founder of the club. (????????????????)

j-o-h-n Saturday 05/13/2017 10:05 AM EST

[joeoconnell]

a very worth while organization, i wish i had been invited to join years ago