EBC-46

I've just been reading some research by an Australian company, qbiotics, on their drug EBC-46. They are making some remarkable claims, but most of their research has been in vitro, with a small amount of in vivo with induced subcutaneous Squamus Cell Carcinomas in mice, which have shown remarkable results. I don't for one minute think it will be of any use for stage 4 metastatic PCa, but it may work as a first stage treatment for early PCa.

Apart from tabloid hysteria, there doesn't appear to be much information. Anyone know anything about this drug (apart from the fact it comes from the berries of a tree)?

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  • see: ncbi.nlm.nih.gov/pmc/articl...

    note: Tigilanol tiglate was previously known as EBC-46

    -Patrick

  • Thanks for that. Read through it with my extremely limited understanding, but it seems to be an extremely interesting drug, taken from a naturally occurring tree. they are starting human trials at the moment I understand, and are looking for volunteers.

  • I keep notes when I read something interesting. Below are my notes. It made the nightly news here in Oz about June last year I think.

    Blushwood

    1 - LINK abc.net.au/news/2014-10-07/...

    Scientists have been surprised by the rapid cancer-fighting properties of a berry found only in Far North Queensland. An eight-year study led by Dr Glen Boyle, from the QIMR Berghofer medical research institute in Brisbane, found a compound in the berry could kill head and neck tumours as well as melanomas. An experimental drug derived from the berry, EBC-46, has so far been used on 300 animals, including cats, dogs and horses. Dr Boyle said in 75 per cent of cases, the tumour disappeared and had not come back. "There's a compound in the seed - it's a very, very complicated process to purify this compound and why it's there in the first place, we don't know," he said. "The compound works by three ways essentially: it kills the tumour cells directly, it cuts off the blood supply and it also activates the body's own immune system to clean up the mess that's left behind."There were no side effects, but what amazed scientists most was how fast it worked: the drug took effect within five minutes and tumours disappeared within days.The EBC-46 drug was derived from a berry that grows on the blushwood tree. (Supplied: QIMR Berghofer Medical Research Institute) “The surprising thing for us and the thing that we don't see very often is the speed with which this occurs," Dr Boyle said. "Usually when you treat a tumour it takes several weeks for it to resolve, but this is very, very rapid.

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