Reversing Prostate Cancer Lineage Plasticity To Reverse ADT Sensitivity

[wagscure259]

A Preliminary Study Out Of Roswell Park Research Targets 2 Gatekeeper Genes To Prevent And Perhaps Reverse Therapeutic Resistance To ADT . One Can Only Hope ! ncbi.nlm.nih.gov/pubmed/280... ncbi.nlm.nih.gov/pubmed/280...

[pjoshea13]

In my post of yesterday:

"Metformin & the Epithelial–Mesenchymal transition [EMT]"

the plasticity involved in the Epithelial–Mesenchymal transition helps the cancer in two ways: (1) treatment evasion & (2) increased metastasis potential. The emphasis in my post was on metastasis, but a number of the EMT papers that I accessed stressed treatment resistance.

-Patrick

[wagscure259 in reply to pjoshea13]

I read your excellent post of yesterday which functionally may presently be a more applicable approach for those of us ( myself included ) that while possessing distant metastasis remaining anti-androgen sensitive , the EMT transition may be more accessible as you pointed out via Metformin and other substances . The epigenetic approach being researched at Roswell Park ( and other centers ) if effective in humans , versus the mouse model in the study , there may be a way to reverse the castration resistant patient by a different method including inhibition of the transcription factor SOX2 thus allowing expression of the tumor suppressors TP53 and RB1 . Apparently SOX2 functions to allow a transition from AR dependent luminal epithelial cells to AR independent basal like cells . EDWARD

[Hidden]

How did you run across these articles?

Nice to see something out of Roswell, and MSK+Weill is in there too.

[wagscure259 in reply to Hidden]

on a Prostate Cancer Foundation Facebook Post . There are also 2 you tube videos by 2 of the researchers but I was unable to share those from my I-Pad to this site . - EDWARD

[Hidden in reply to wagscure259]

youtube.com/watch?v=4zrUWVi...(Not working as expected?)

youtube.com/watch?v=Ak3mqWA...(Not working as expected?)

[gusgold]

The Roswell Park research is interesting but probably years away from clinical application. I think the best bet is a breakthrough on the Check Point Inhibitors for PCa