Reversing Prostate Cancer Lineage Plasticity To Reverse ADT Sensitivity
A Preliminary Study Out Of Roswell Park Research Targets 2 Gatekeeper Genes To Prevent And Perhaps Reverse Therapeutic Resistance To ADT . One Can Only Hope ! ncbi.nlm.nih.gov/pubmed/280... ncbi.nlm.nih.gov/pubmed/280...
In my post of yesterday:
"Metformin & the Epithelial–Mesenchymal transition [EMT]"
the plasticity involved in the Epithelial–Mesenchymal transition helps the cancer in two ways: (1) treatment evasion & (2) increased metastasis potential. The emphasis in my post was on metastasis, but a number of the EMT papers that I accessed stressed treatment resistance.
I read your excellent post of yesterday which functionally may presently be a more applicable approach for those of us ( myself included ) that while possessing distant metastasis remaining anti-androgen sensitive , the EMT transition may be more accessible as you pointed out via Metformin and other substances . The epigenetic approach being researched at Roswell Park ( and other centers ) if effective in humans , versus the mouse model in the study , there may be a way to reverse the castration resistant patient by a different method including inhibition of the transcription factor SOX2 thus allowing expression of the tumor suppressors TP53 and RB1 . Apparently SOX2 functions to allow a transition from AR dependent luminal epithelial cells to AR independent basal like cells . EDWARD
How did you run across these articles?
Nice to see something out of Roswell, and MSK+Weill is in there too.
on a Prostate Cancer Foundation Facebook Post . There are also 2 you tube videos by 2 of the researchers but I was unable to share those from my I-Pad to this site . - EDWARD
The Roswell Park research is interesting but probably years away from clinical application. I think the best bet is a breakthrough on the Check Point Inhibitors for PCa
dissection helps on long term endpoints. ncbi.nlm.nih.gov/pubmed/303...
ec_Oncology_Update_Active The full study in Lancet Oncology thelancet.com/journals/lano...
ginger as a cancer fighting substance. ncbi.nlm.nih.gov/pmc/articl...
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