When the GFR is <40 patients taking MPA(Mychophenolic Acid) Mofetil at the therapeutic doses end up with GI intolerance due to excessive toxicity of glucuronides from the cellcept metabolism.
So, I looked up inhibitors for glucuronides and found curcumin.
Here is a study showing that curcumin not only inhibits glucuronides but increases the mychophenolic acid. pretreatment of 100mg/kg curcumin increased MPA effectiveness 9 fold.
So far, no nausea for my mom at 1gm per day where she always got nausea and vomitting after one day. I am giving her 885mg curcumin with each mofetil dose and an extra one inbetween her twice per day dosings of mofetil.