When the GFR is <40 patients taking MPA(Mychophenolic Acid) Mofetil at the therapeutic doses end up with GI intolerance due to excessive toxicity of glucuronides from the cellcept metabolism.
So, I looked up inhibitors for glucuronides and found curcumin.
Here is a study showing that curcumin not only inhibits glucuronides but increases the mychophenolic acid. pretreatment of 100mg/kg curcumin increased MPA effectiveness 9 fold.
So far, no nausea for my mom at 1gm per day where she always got nausea and vomitting after one day. I am giving her 885mg curcumin with each mofetil dose and an extra one inbetween her twice per day dosings of mofetil.
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mrtmeo
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Interesting. But please do make sure that the doctor who prescribes the Mycophenolate for your mom knows that she is taking a supplement. It might be particularly important if it increases the effectiveness of the MMF as this might reduce her immune system too much.
You almost read my thoughts Richard! I am on MMF, along with other drugs and have been advised NOT to take 'supplements/herbal remedies' without the approval of my doctors/consultants.
Now I know, honestly I do, how tempting it is to take something that appears to work-now I know that this is considerably different but.....A young girl recently took, only about six, 'unlicensed diet pills' and it killed her-in fact she died in agony, despite the hospital best attempts. A lesson to us all perhaps? granted she did buy this 'drug' on the internet but still!
Ok now I've frightened you all 'half to death' I'll b-gger off.
Sorry to 'rain on your parade'- all I'm really trying to say is 'Please, please Do be carful!
I agree with both Richard and Andrew. Please do tell your mom's doctor.
Susan
I see both good and no so good reviews (proper peer reviewed articles) on curcumin. I know lots of people are on this knowing the risks. Personally, I have no faith in supplements.
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