The relevance of T3 in the management of hypothyroidism

[buddy99]

Sorry if this has been posted already. In that case, here we go again ;):

ncbi.nlm.nih.gov/pmc/articl...

[Charlie-Farley]

Thank you buddy99 - appreciate! We don’t all see the first posting of a paper (if there has been one). 🤗

[RedApple Administrator]

Thanks for posting buddy99, we have new members joining all the time, so chances are many here won't have seen it before.

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Published online 2022 Feb 28. doi: 10.1016/S2213-8587(22)00004-3

Authors: Domenico Salvatore, Tommaso Porcelli, Matthew D Ettleson, and Antonio C Bianco

Abstract

Levothyroxine monotherapy has been the standard of care for treatment of hypothyroidism for more than 40 years. However, patients treated with levothyroxine have relatively lower serum tri-iodothyronine (T3) concentrations than the general population, and symptoms of hypothyroidism persist for some patients despite normalisation of thyroidstimulating hormone (TSH) concentrations. The understanding that maintenance of normal T3 concentrations is the priority for the thyroid axis has redirected the clinical focus to serum T3 concentrations in patients with hypothyroidism. This Personal View explores whether it is currently feasible to identify patients who could be considered for liothyronine supplementation in combination with levothyroxine. Genetic profiling stands out as a potential future tool to identify patients who do not respond well to levothyroxine due to suboptimal peripheral thyroxine (T4) activation. Moreover, new slow-release liothyronine preparations are being developed to be trialled in these symptomatic patients, in an attempt to restore T3 concentrations and provide conclusive results for the use of T4 plus T3 combination therapy.

ncbi.nlm.nih.gov/pmc/articl...

[Brightness14]

Thank you, very interesting I have printed out a copy for future reference.

[serenfach]

I have just sent a copy of this to my Endo (a diabetic specialist who hates T3)! Bet he does not read it though, coming from a mere mortal!

Thanks for flagging this.