ratio level

[Gcart]

my ratio ,I have used the calculator, is 5.143

Can anyone inform me what that is telling me please.

thank you

[SeasideSusie Remembering]

Presumably you're talking about FT4 : FT3 ratio?

Can you add results and ranges .

What thyroid meds do you take ?

When did you take last dose before test?

You've just had Covid, was this test done after you had Covid ? If so how long and as the booster messed with your levels do you think Covid might have ?

[Gcart in reply to SeasideSusie]

TSH. 0.2. 0.27 -4.2

Ft4. 18. 12-22

Ft3 3.5. 3.2-6.8

Taking ; 75 mcg thyroxine

5 mcg T3

Last dose , I followed as advised here .

Covid neg as from 18 th December

Test done yesterday and posted yesterday results back 5pm today . Full marks for monitor my health !!

I was checking before I have a GP authorised test , who is waiting in the sidelines !

My cholesterol level is high 7.5

D 3 66

Weight 49 kilos 5’6”

[SeasideSusie Remembering in reply to Gcart]

The ratio of T4 to T3 tells us how well, or not, we convert. You take T3 therefore it's not relevant, we can only tell how we convert when on Levo only, so forget about ratio.

Those results show that you could do with an increase in your dose of T3, due to your very low FT3 and FT4 being 60% through range, assuming they are accurate and haven't been affected by Covid

[Gcart]

thank you ver much ss

Guess that was the answer I wanted !

Gp. Has put thyroxine done on my scripts to 50 mcg Not taking into account of my t3

I tell them I take it snd the way I obtain it !

Can’t image what would happen if I had reduced to only 50mcg Thyroxine

Managed to be ahead so can manage as I have enough . Always keep ahead is my motto ! Learnt it from this forum

Thanks a million

[Gcart]

another ask please

On 75 thyroxine only,

GP wanted me to drop to 50 ! October 22

I wouldn’t do that but did stop taking T3 for 6weeks to see outcome

did test on MMF same time etc. waited 6 weeks

TSH. 0.37 0.27-4.2

T4. 15.4. 12-22

T3. 2.7. 3.1-6.8

If relevant ratio 5.704

Does that tell me anything to help maintain thyroxin on my script ?

It is still only written up for 50 mcg

I think I would be done for !🤨

[tattybogle in reply to Gcart]

The previous results ALREADY give you ammunition to keep the 75mcg dose . Are these the TSH results the NHS are looking at , or do they have thier own reuslt that shows a lower TSH level ?

TSH. 0.2. [0.27 -4.2]

Ft4. 18. [12-22]

Ft3 3.5. [3.2-6.8]

(Taking ; 75 mcg thyroxine & 5 mcg T3)

TSH 0.2 is not low 'enough' to increase the 'risks'

GP will say "low TSH increases heart and bone risks" , and it does ,.... but when looked at carefully the research actually shows that risks of "low BUT NOT SUPRESSED" TSH (on levo) do not increase until TSH is below 0.04 .

It shows that risks of 'low but not supressed' TSH 0.04 - 0.4 are no greater than risks for TSH 0.4-4 (in range).

Ask GP to read this paper which proves this~ (it is one of the papers used to make the NHS guidelines about low TSH) academic.oup.com/jcem/artic... Serum Thyroid-Stimulating Hormone Concentration and Morbidity from Cardiovascular Disease and Fractures in Patients on Long-Term Thyroxine Therapy

Robert W. Flynn, Sandra R. Bonellie, Roland T. Jung, Thomas M. MacDonald, Andrew D. Morris, Graham P. Leese

"Context: For patients on T4 replacement, the dose is guided by serum TSH concentrations, but some patients request higher doses due to adverse symptoms.

Objective: The aim of the study was to determine the safety of patients having a low but not suppressed serum TSH when receiving long-term T4 replacement.

Design: We conducted an observational cohort study, using data linkage from regional datasets between 1993 and 2001.

Setting: A population-based study of all patients in Tayside, Scotland, was performed.

Patients: All patients taking T4 replacement therapy (n = 17,684) were included.

Main Outcome Measures: Fatal and nonfatal endpoints were considered for cardiovascular disease, dysrhythmias, and fractures. Patients were categorized as having a suppressed TSH (≤0.03 mU/liter), low TSH (0.04–0.4 mU/liter), normal TSH (0.4–4.0 mU/liter), or raised TSH (>4.0 mU/liter).

Results: Cardiovascular disease, dysrhythmias, and fractures were increased in patients with a high TSH: adjusted hazards ratio, 1.95 (1.73–2.21), 1.80 (1.33–2.44), and 1.83 (1.41–2.37), respectively; and patients with a suppressed TSH: 1.37 (1.17–1.60), 1.6 (1.10–2.33), and 2.02 (1.55–2.62), respectively, when compared to patients with a TSH in the laboratory reference range. Patients with a low TSH did not have an increased risk of any of these outcomes [hazards ratio: 1.1 (0.99–1.123), 1.13 (0.88–1.47), and 1.13 (0.92–1.39), respectively].

Conclusions: Patients with a high or suppressed TSH had an increased risk of cardiovascular disease, dysrhythmias, and fractures, but patients with a low but unsuppressed TSH did not. It may be safe for patients treated with T4 to have a low but not suppressed serum TSH concentration.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

This one shows long term low TSH ( with fT4 in range) does not significantly affect bone density healthunlocked.com/thyroidu... longterm-subclinical-hyperthyroidism-does-not-affect-bone-density-in-patients-having-had-thyroid-ablation-for-cancer

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Also See my reply to this post (3rd reply down) for links to useful discussions on the subject of Low TSH / Risk vs Quality of life healthunlocked.com/thyroidu... feeling-fine-but-tsh-is-low

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

So even without showing them the results after 6 weeks without T3, you still have a very strong argument to get the 75mcg prescription reinstated . (mind you .. since most gp's don't read the detail and just look at the what the NICE guideline's choose to spoon feed them , you probably will have to have an 'argument' )

[Gcart in reply to tattybogle]

thank you tatty

These are NHS one result is I believe (get a bit mixed)

The lady one is just this week , MMH .

Will do GP bloods in a couple of weeks having had Covid to get over .

Will keep fighting to stay where I was without reduction .

Constipation now , big time!

Cholesterol up to 7.5 from about 6 if I remember .

This going on for about 5 months now , so tired of it .

[SeasideSusie Remembering]

TSH. 0.37 0.27-4.2

T4. 15.4. 12-22

T3. 2.7. 3.1-6.8

Does that tell me anything to help maintain thyroxin on my script ?

With FT4 just 34% through range and FT3 below range those results are saying that your actual hormone levels (FT4/FT3) are too low (I expect you felt quite unwell with those results) and that an increase in dose is indicated.

When on Levo only most hypo patients tend to feel best when TSH is 1 or below with FT4 and FT3 in the upper part of their reference ranges. Doctors tend to panic when they see a low TSH and use that to reduce dose, and although TSH is useful for diagnosis once on thyroid hormone replacement it's the FT4/FT3 that should be used as a guide (along with symptoms) to dose adjustment, and it's FT3 that's more important as that's what tells us if we are over medicated.