This new article is a comprehensive review of the relationship between episodes like subclinical hypothyroidism and heart problems and life threatening possibilities. Very comprehensive and a very good review of what is now known.
Thanks for posting an Interesting but technically difficult read. It all seems very complex. So much for thyroid disorder being easy to treat. Good to know it’s not as simple as is often claimed, even if it makes it tricky for us.
Bit depressing that their solution to improving risk from heart problems on T4 monotherapy is to give less Levothyroxine to reduce free T4 /T4 levels.
First it was TSH now free T4/T4 is the weapon of choice to allow under medication of thyroid hormones to persist on the pretence of it being good for us because it’s saving us from heart problems.
I didn’t see any mention of combination therapy as a way of mediating the problem and not leaving us half alive but with a hearty heart powering a living wreck.
Combination therapy certainly got rid of my awful heart pains, how it withstood the thyroid hormone chaos it was put through I really don’t know but I don’t think the ticker is what it used to be. There’s lots of heart problems in my family with or without thyroid disease added into the mix . Even more complicated? But something has got to get you in the end.
It’s troubling that affects comparatively young people though.
I have posted before on this forum that I had a total heart block due to the non conversion of T4-T3 and now have a pacemaker. I wouldnt take T4 again and have to self source T3 as I can’t get it prescribed. The four other patients in my heart ward all had thyroid problems.
oh SueHG so sorry to hear that, I hope you are doing better and the pacemaker is helping. I wish the complications and subtleties of thyroid problems were taken more seriously.
Its suddenly easier on the NHS now the price is down. Check your local prescribing committee guidelines online to see what they say. In my area the GP can now prescribe again under consultant instruction.
'Elevated FT4... primary hyperthyroidism' in this bit of the text:
Integrating the available evidence suggests a dual etiology of elevated FT4 concentration, comprising both ensuing primary hypothyroidism and a raised set point of thyroid function, e. g. in the context of psychiatric disease, chronic stress and type 2 allostatic load
Don't they mean 'hyperthyroidism '?
If I have completely misunderstood, can someone explain please?
No, these are cases where FT4 is raised because the stresses have inhibited T4 conversion to T3 in the body (not primarily the thyroid gland). It's a kind of nonthyroidal illness, as described. This can come in many forms. TSH is probably not raised.
thanks for sharing this diogenes I was brachycardic on T4 but now on T3 only I have peaks of tachycardia. Got some cardio tests this week so it interesting to read the article.
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