An invitation: Novel uses of T3 & T4 for dermatological applications

[helvella]

Professor Paus has made what appears an interesting suggestion - that we discuss T3 and T4 and pass on suggestions.

Of course, I am happy to pass on anything to him. So please make suggestions in response!

Well, how about making that a discussion item in your forum: invitation of clever ideas and suggestion of potential industry targets, geared towards identifying paths to fund research into novel uses of T3 & T4 for dermatological applications...?

Ralf Paus, MD, FRSB

Professor of Dermatology

I'll wait a while to see what, if any, suggestions are made and then pass them on.

Earlier post:

healthunlocked.com/thyroidu...

[diogenes Remembering]

First of all, if we are going to be able to make suggestions, we need to know the enemy: ie what conditions is he considering as candidates? It's no use waving hands in the air if we don't know what is being aimed at.

[helvella Administrator Thyroid UK in reply to diogenes]

In the earlier reply, he was specific about wound healing being their current target.

[diogenes Remembering in reply to helvella]

Then perhaps to partially copy the Voltarol absorption medium with T3 or T3 sulphate or T3 glucuronide as the active ingredient. I don't think T4 would work because of lack of conversion.

[nightingale-56 in reply to diogenes]

Although I like this idea, might the application of T3 onto our skin raise and cause problems with our blood range? It would be good to get our T4/T3 into range and so improve a lot of other health problems possibly.

[diogenes Remembering in reply to nightingale-56]

I think the topical gel and contents would not significantly enter the bloodstream.

[RedApple Administrator]

I'm a little confused. Is it the novel uses of T3 and T4, or the ideas for funding that is being put forward for discussion?

[helvella Administrator Thyroid UK in reply to RedApple]

I think he is desperate for funding but is asking for any ideas.

[fuchsia-pink in reply to helvella]

Maybe I'm being particularly slow today, but as far as I know, there hasn't been a decent large-scale study on T3 and hypothyroidism ... I for one, would be very interested to see something that proves my hunch that it's not a placebo But also

* why do some people who are poor converters genuinely not take to it

* why do some people tolerate lio but not levo

* is there any correlation at all between taking lio and heart, bone density etc problems

There was something in an earlier post about T3 meds and Covid - and there seems to be endless Covid-related cash swilling around - so could also possibly expand into whether there is any correlation between patients taking lio [and patients who should be taking lio because their T3 is say less than half-way through range] and

*not getting Covid at all/ getting it only asymptomatically/ not needing ventilators/ not getting long Covid

I understand that wound healing can be a big issue, but I'm not sure how T3 and T4 connect to the problem

[TSH110 in reply to helvella]

Treating Covid toes? Might get some dosh in.

[humanbean]

I've had dyshidrotic eczema (also known as pompholyx) and ordinary dry dermatitis-type eczema for nearly 50 years and for 40 of those years the treatment options were poor and very ineffective. Long term use of steroid creams has the side effect of thinning skin which makes it very fragile and more prone to damage. Optimising nutrients and improving my thyroid hormone levels over the last 10 years or so has reduced the problem but not eliminated it. It would be nice to get rid of it completely.

Perhaps having a T3 cream might be more effective for eczema than steroid creams without the side effects?

Although it doesn't affect me personally, I'm also curious whether T3 cream could have an effect on psoriasis.

And what about rosacea?

Or those conditions where people get really gross crusty skin on their heads (I don't know what it is called but it looks like the dandruff from hell)?

And what about acne? Or boils?

Cradle cap?

[tattybogle in reply to humanbean]

i agree, it would be a good idea to try t3 directly on pompholyx, (i can provide the pompholyx )I'm pretty sure pompholyx has a connection to thyroid judging by the amount of people on here with it. and using steroid cream which thins the skin to help it heal is counter productive, and i try to avoid it unless i really have to.

Other things have been suggested like b12 cream , but didn't seem to help mine , which has been unusually continuous this year. When i get some t3 i'm going to come up with a way to apply some to my fingers and see what happens.

I do wonder if pompholyx is worse with low T3.

So i think he needs to apply find a cohort of long covid patients with pompholxy , cos presumably there is more funding for long covid , thanT3 research

.... maybe put him in touch with the Earwax trial people ....if you can get funding for earwax trials who knows

[penny in reply to humanbean]

Vitamin D? See Dr Coimbra’s offerings.

[humanbean in reply to penny]

I take vitamin D every day, but still get eczema in some places. It isn't as bad as it used to be when I was much younger, but I've never managed to eliminate it entirely.

[penny in reply to humanbean]

Hi humanbean, did you look at The Coimbra Protocol? Dr Coimbra advocates high does of vitamin D, but only under medical supervision.