Liquid/oral levo side effects

[Ela_peraj]

Hello all. Has anyone started the liquid levo and noticed any side effects?? I am on (Mercury farmer) UK brand.

[helvella Administrator]

Some people find they cannot take the substantial amount of glycerol they contain.

This might not be what has been described in medical literature as "glycerol intolerance", but a lesser issue. Sufficient to make taking levothyroxine oral solutions an unsatisfactory option.

[Ela_peraj in reply to helvella]

What as in horrible taste?

[helvella Administrator in reply to Ela_peraj]

No. It tends to be fairly pleasant and sweet. But it can cause "upset stomach" types of issue.

[Hibs1 in reply to helvella]

Definitely

[Hibs1 in reply to helvella]

That's me

[Ela_peraj in reply to Hibs1]

Oh as in bloating? Just give people bad stomach ache?

[posthinking01]

Can I ask what side effects you are experiencing?

[Ela_peraj in reply to posthinking01]

None at the moment. Is only day 3.

I was on accord tablet form since Feb 20 but the maze and possibly gluten cross contamination was has no made my vili flat a I am a celiac. So been put on oral 2.5ml. I've been reading that sometimr the oral is better for obsorption as well.

[Hibs1]

I had the tevo liquid with the glycerol with awful side effects, severe bloating and cramps

[helvella Administrator in reply to Hibs1]

I think all levothyroxine oral solutions are based on glycerol.

Levothryoxine is almost insoluble in neutral and acidified water. The underlying process of making them consists of dissolving the levothyroxine in an alkaline solution. Then mixing that with glycerol - it stays in solution. Finally, adding some acid to neutralise the alkali. Amazingly, the levothyroxine still remains in solution.

UK Levothyroxine Oral Solutions

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Last updated 12/09/2020.

This is a list of currently marketed levothyroxine oral solutions in the UK.

Please note that re-branding (whether by a manufacturer or as an ‘own label supplier’ - which has happened with several products) does not mean any change to formulation.

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🔹 Advanz (marketing authorisation holder) – branded both “Mercury Pharma Levothyroxine Oral Solution” and “Mercury Pharma Eltroxin Levothyroxine Oral Solution” which are identical

🏭 manufactured by FAMAR Netherlands BV

  25 micrograms per 5ml   PL 12762/0459

  50 micrograms per 5ml    PL 12762/0461

  100 micrograms per 5ml    PL 12762/0462

🟢 PIL 25, 50 & 100 mhraproducts4853.blob.core....

🟣 SPC 25 mhraproducts4853.blob.core....

🟣 SPC 50 mhraproducts4853.blob.core....

🟣 SPC 100 mhraproducts4853.blob.core....

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🔹 Creo (marketing authorisation holder)

🏭 manufactured by Quantum Pharmaceutical Limited

  25 micrograms/5ml    PL 31862/0035

  50 micrograms/5ml    PL 31862/0036

  100 micrograms/5ml    PL 31862/0037

  125 micrograms/5ml    PL 31862/0038

🟢 PIL 25, 50, 100 & 125 mhraproducts4853.blob.core....

🟣 SPC 25 mhraproducts4853.blob.core....

🟣 SPC 50 mhraproducts4853.blob.core....

🟣 SPC 100 mhraproducts4853.blob.core....

🟣 SPC 125 mhraproducts4853.blob.core....

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🔹 Ten Pharma (marketing authorisation holder)

🏭 manufactured by BCM Limited

  25 micrograms/5ml  PL 34777/0003

  50 micrograms/5ml   PL34777/0004

  100 micrograms/5ml  PL34777/0005

🟢 PIL 25 mhraproducts4853.blob.core....

🟢 PIL 50 mhraproducts4853.blob.core....

🟢 PIL 100 mhraproducts4853.blob.core....

🟣 SPC 25 mhraproducts4853.blob.core....

🟣 SPC 50 mhraproducts4853.blob.core....

🟣 SPC 100 mhraproducts4853.blob.core....

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🔹 Teva (marketing authorisation holder)

🏭 manufactured by Delpharm Bladel B.V., The Netherlands

  25 micrograms/5ml  PL 00289/1593

  50 micrograms/5ml  PL 00289/1594

  100 micrograms/5ml  PL 00289/1595

🟢 PIL 25, 50 & 100 mhraproducts4853.blob.core....

🟣 SPC 25 mhraproducts4853.blob.core....

🟣 SPC 50 mhraproducts4853.blob.core....

🟣 SPC 100 mhraproducts4853.blob.core....

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🔹 Wockhardt (marketing authorisation holder)

🏭 manufactured by CP Pharmaceuticals Ltd

  25 micrograms/5ml  PL 29831/0493

  50 micrograms/5ml   PL 29831/0494

  100 micrograms/5ml  PL 29831/0495

🟢 PIL 25, 50 & 100 mhraproducts4853.blob.core....

🟣 SPC 25 mhraproducts4853.blob.core....

🟣 SPC 50 mhraproducts4853.blob.core....

🟣 SPC 100 mhraproducts4853.blob.core....

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🔹 – identifies marketing authorisation holder (or equivalent in other countries)

🔸 – identifies ‘own label supplier’ products

🏭 – identifies manufacturers (where known)

🟢 PIL – Patient Information Leaflet

🟣 SPC – Summary of Product Characteristics document

🟢🟣 – Single document combining typical PIL and SPC information

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If there is anything inaccurate in this information, please let me know by Private Message, or on the forum:

healthunlocked.com/user/hel...

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This document is updated whenever I am aware of any changes or enhancements are needed. Please check the Last updated date. The current version is available as a PDF here:

dropbox.com/s/7gfwd3f7127xp...

The PDF version of this document has QR code above this sentence. If your device has a camera and can interpret QR codes, this QR code should take you to the same place as the link and make it easier to download on devices, such as phones and tablets.

[Hibs1 in reply to helvella]

The only one gp was allowed to prescribe was the Teva and is same one used by consultant privately or in her NHS clinic. Wouldn't go near liquid again far too fiddly to administer as I split more than I drank! Fingers not agile enough at 72😒

[McPammy]

I take Levothyroxine liquid. I’m on Ten Pharma. I used to be on Wockhardt but the product was recalled and still pending licensing.

I have no issues with it. The only thing I’d say is that Teva brand is not tolerated by many tablets or liquid. Try taking a different brand. Ten Pharma for me works well.

[Santolina]

Hello. I'm in France and have been on 15 drops of levothyroxine [SERB pharmaceuticals] for the past three weeks. This is a trial to see if I'm absorbing the equivalent of 75mcg tablet. I haven't noticed any change at all but I get tested after two months. The problem? NDT was the only one that made a big difference!

[Ela_peraj]

I take mine and then wash it down with water. That's still OK??

[Hibs1]

I was useless with that. My fingers don't do intricate or delicate as too stiff.

[helvella Administrator in reply to Hibs1]

The Guardian has a current article about the difficulties some have with syringes.

Tries to be light-hearted and amusing but the underlying issue is (of course) serious. Quite a lot of comments - which include quite a bit that might be of interest.

theguardian.com/commentisfr...

[Hibs1 in reply to helvella]

Will have a read later, thanks for that

[Hibs1 in reply to helvella]

Read a lot of comments and the levo one at the end was me. Bad eyesight and stiff fingers and prone to spilling things and knocking things over due to vision. Spoons the best of a bad lot

[Ela_peraj]

I am on mercury pharma. Is not part of Teva?

[helvella Administrator in reply to Ela_peraj]

No. Mercury Pharma is owned by Advanz.

If you look at the earlier part of this thread, you will find another response by me which lists all UK levothyroxine oral solutions including the companies and the manufacturers.