J Clin Transl Endocrinol. 2018 Dec; 14: 25–33.P... - Thyroid UK

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J Clin Transl Endocrinol. 2018 Dec; 14: 25–33.Published online 2018 Sep 26. doi: 10.1016/j.jcte.2018.09.003

Jenny583 profile image
5 Replies

I still can't figure out how to make an article title "clickable" - (must be brain dead!)

Something in this article stood out for me - about a survey that found that rather than being the rare disease that is entrenched in the minds of the medical profession, "central hypothyroidism" appears to occur in 1 in 41 people!

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Jenny583
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jimh111 profile image
jimh111

Thanks for this. I haven't looked at it yet but the 41:1 figure relates to the relative incidence of primary to central hypothyroidism. i.e. each year 41 times as many people develop primaray hypothryoidism as do central hypothyroidism. They give the prevalence (how many have it) of central hypothyroidism as 'ranging from 1:16,000 to 1:120,000'. So central hypothyroidism is very rare.

Jenny583 profile image
Jenny583 in reply to jimh111

Thanks for pointing that out Jim111. Must have read through too quick, I will read through again & correct this xx

helvella profile image
helvellaAdministratorThyroid UK

You really don't want to put clickable links into thread subjects. It causes technical problems!

I think this is what you wanted to refer to:

Less known aspects of central hypothyroidism: Part 1 – Acquired etiologies

sciencedirect.com/science/a...

Jenny583 profile image
Jenny583 in reply to helvella

Thanks helvella, I am fairly new to computers, & very new to social media. I had better leave the technical stuff to the experts!

I would like to say that I got a phone call from the surgery of the new practice, the receptionist wanted to know if I had had an appointment with a different Endocrinologist.

I didn't think that promise would be followed up - as no Dr that I have ever encountered kept their promises.

I also asked if they would send a printout of my last test, which I have just received a bill for.

She said she would! maybe things will get sorted? I hope so.

Jenny583 profile image
Jenny583

Correction! to above, as jimh111 quite rightly pointed out the following is 41-1 of patients with hypothyroidism, though the author does point out that a large number remain undiagnosed. Here below is what I saw. ---

----"Over the same 12-month period, the ratio of primary to secondary hypothyroidism detected by the above test strategy was 20:1 [11]. Such 20:1 ratio of primary to secondary hypothyroidism [11] might appear grossly overestimated in view of the aforementioned widely held opinion on the rarity of CH [9]. However, the 20:1 ratio is consistent with what can easily be calculated based on a recent meta-analysis [13]: the incidence of hypothyroidism in Europe is 226 per 100,000 per year, which divided by 5.5/100,000 (incidence of CH according to Wardle et al. [11]) equals 41: 1.

In a Spanish study, the frequency of diagnosed hypopituitarism was significantly higher in the year 1999 (45.5/100,000/year) compared to year 1992 (29/100,000/year), but with similar distribution of etiologies: pituitary tumors accounting for around 60%, extrapituitary tumors for 10%, and non-tumoral causes for approximately 30% [14]. Thus, in 1999 the incidence of CH from non-tumoral causes was 10/100,000/year, which is again an order of magnitude similar to the incidence of CH according to Wardle et al. [11]."

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