Interference in Thyroid Hormone Assays

[diogenes]

Sometimes on this site, results are recorded which are confusing and are actually artefactually distorted, giving unnecessary alarm and perhaps wrong conclusions and treatment. Here is a paper which comprehensively reviews these difficulties (downloadable):

Interferences With Thyroid Function Immunoassays: Clinical Implications and Detection Algorithm

July 2018Endocrine reviews 39(5)

DOI: 10.1210/er.2018-00119

Project: Thyroid interferences

Julien Favresse, Mc Burlacu, Dominique Maiter, Damien Gruson

It is a useful paper to bring to the attention of a doctor if the results look suspiciously out of line

[Parbrook]

Thank you

academic.oup.com/edrv/artic...

[m7-cola]

Thank you for posting. I welcome this paper. It aligns with my view that clinical signs and symptoms are a more reliable source of evidence of adequate/inadequate medication that 'one size fits all ' blood tests. I am pleased to say that my endocrinologist seems to agree. Unfortunately many on this forum have suffered from doctors with 'tunnel vision' who stick rigidly to test scores.

[LAHs]

Wow, quite a paper, I will never understand all of it but that error due to macro TSH on the TSH measurement was astounding, what was it, 499 instead of 90, scary. It tells me that our TSH and T4 docs are in the stone-age. I was going to say what M7-cola said, " that clinical signs and symptoms are a more reliable source of evidence of adequate/inadequate medication". If you take that approach then you "iron out" all of the many inaccuracies and you get down to where the rubber hits the road: what's it's effect on me!

[LindaC]

Thank you - most interesting!

[kissemiss]

Thank you so much for this interesting piece of research on Thyroid interferences on the tsh test results.