D2 polymorphism and tendency to hypothyroidism and diabetes

[diogenes]

A paper discussing the clinical significance of D2 deiodinase polymorphism in humans

Clinical significance of type 2 iodothyronine deiodinase polymorphism

September 2018

Expert Review of Endocrinology & Metabolism 13(5)

DOI: 10.1080/17446651.2018.1523714

Fabio Maino, Silvia Cantara, Raffaella Forleo, Maria Grazia Castagna

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[Naomi8]

Is this the same polymorphism as DI02 ?

[diogenes Remembering in reply to Naomi8]

Yes

[humanbean]

Link to the abstract : tandfonline.com/doi/abs/10....

Link to the full paper/article : sci-hub.tw/10.1080/17446651...

The full paper link could disappear at any time.

[Hormone-hell]

Very interesting as I am heterozygous as well as other family members and nearly everyone has diabetes or thyroid disease!

[TSH110 in reply to Hormone-hell]

Me too there is no way I convert T4 to T3 efficiently. All my close maternal female relatives have or have had (now dead) thyroid disorders from at least my grandmother. All my sisters have problems, in our generation it is one hyper and three hypos. I am the only one with real problems on Levothyroxine monotherapy but I do not know if any of them have/had the polymorphism too. I now take NDT and feel much better. No one has diabetes.

[UrsaP]

Thank you for posting diogenes . linda96 Have you seen this one?

[sy28]

thanks for posting