How to take levothyroxine. I am unsure how to get the most from my medication. I work shifts. 3 days on 3 days off. 6am til 6 pm. When working I get up at 4.30am I take tablets then and wait 30 mins before my cuppa. Out of door at 5.20 so have to eat with my cuppa. Is this long enough. I cannot drink or eat then until 9.30. On my days off I obviously don't get up at 4.30. So could be a difference of a few hours over the different shifts. At night ihave a similar problem. I get home at 7 and need to eat and be in bed by 9.45. So cannot take then. Please help. When should I take them????????