It really is true that all of us with hypo are different. I was taking synthroid for 14 years and couldn't lose weight. Then last October after doing a lot of research, I started taking Armour. By May I had lost 40 lbs.!! I did nothing else to cause the weight loss. But I, too have the same problem with sagging skin, it's awful. I don't want to lose anymore weight, I feel too thin. I've lost a few more lbs. I started at 174 lbs. and now weigh 128 (obviously I'm from the US. This disease is so weird. I'm going to take the advice I read on here. Thank you so much.