This paper is unlikely to be of specific help to anyone - but hopefully will be of interest to someone! It talks about birds and mammals rather than humans.
Lest anyone suggest that thyroid is simple, this is yet another set of complexities.
REVIEW ARTICLE
published: 26 February 2014
doi: 10.3389/fendo.2014.00019
Thyroid hormone and seasonal rhythmicity
Hugues Dardente 1,2,3,4
*, David G. Hazlerigg 5
and Francis J. P. Ebling 6
1 Physiologie de la Reproduction et des Comportements, INRA, UMR085, Nouzilly, France
2 CNRS, UMR7247, Nouzilly, France
3 Université François Rabelais de Tours, Tours, France
4 Institut français du cheval et de l’équitation, Nouzilly, France
5 Department of Arctic and Marine Biology, University of Tromsø, Tromsø, Norway
6 School of Life Sciences, University of Nottingham, Nottingham, UK
Edited by:
Frédéric Flamant, Ecole Normale
Supérieure de Lyon, France
Reviewed by:
Valerie Simonneaux, Centre National
de la Recherche Scientifique, France
Sulay Tovar, University of Cologne,
Germany
*Correspondence:
Hugues Dardente, INRA, UMR85
Physiologie de la Reproduction et des
Comportements, CNRS, UMR7247,
Université François Rabelais de Tours,
IFCE, F-37380 Nouzilly, France
e-mail: hdardente@tours.inra.fr
Living organisms show seasonality in a wide array of functions such as reproduction, fatten-
ing, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain
the alignment of annual rhythms with predictable changes in the environment.The appropri-
ate physiological response to changing photoperiod in mammals requires retinal detection
of light and pineal secretion of melatonin, but extraretinal detection of light occurs in birds.
A common mechanism across all vertebrates is that these photoperiod-regulated systems
alter hypothalamic thyroid hormone (TH) conversion. Here, we review the evidence that a
circadian clock within the pars tuberalis of the adenohypophysis links photoperiod decod-
ing to local changes of TH signaling within the medio-basal hypothalamus (MBH) through
a conserved thyrotropin/deiodinase axis. We also focus on recent findings which indicate
that, beyond the photoperiodic control of its conversion,TH might also be involved in longer-
term timing processes of seasonal programs. Finally, we examine the potential implication
of kisspeptin and RFRP3, two RF-amide peptides expressed within the MBH, in seasonal
rhythmicity.
Full paper freely available here: