Research confirms seasonal (and daily) variation of immune system responsiveness

Heard on BBC World Service Science Hour, which means you can probably download / listen to interview if you're interested.

cam.ac.uk/research/news/sea...

Interview with Professor Todd pricked my ears when he was discussing intrinsic human immune system's ability to react, being confirmed as seasonal plus daily. Yes, we've suspected it but this is hard research confirming it.

Something he said made me hope my GP was listening. That is, this research confirms that what time of day we take medications really may make a difference. This is something i find true for me but which my GP categorically denies.

Hope this research might eventually lead to improved treatment for all sorts of autoimmune diseases, including us Hashis folks.

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  • Saw this the other day:

    Nat Rev Endocrinol. 2014 Aug;10(8):466-75. doi: 10.1038/nrendo.2014.78. Epub 2014 May 27.

    Circadian clock control of endocrine factors.

    Gamble KL1, Berry R2, Frank SJ2, Young ME3.

    Author information

    1Division of Behavioural Neurobiology, Department of Psychiatry, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA.

    2Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA.

    3Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA.

    Abstract

    Organisms experience dramatic fluctuations in demands and stresses over the course of the day. In order to maintain biological processes within physiological boundaries, mechanisms have evolved for anticipation of, and adaptation to, these daily fluctuations. Endocrine factors have an integral role in homeostasis. Not only do circulating levels of various endocrine factors oscillate over the 24 h period, but so too does responsiveness of target tissues to these signals or stimuli. Emerging evidence suggests that these daily endocrine oscillations do not occur solely in response to behavioural fluctuations associated with sleep-wake and feeding-fasting cycles, but are orchestrated by an intrinsic timekeeping mechanism known as the circadian clock. Disruption of circadian clocks by genetic and/or environmental factors seems to precipitate numerous common disorders, including the metabolic syndrome and cancer. Collectively, these observations suggest that strategies designed to realign normal circadian rhythmicities hold potential for the treatment of various endocrine-related disorders.

    PMID:

    24863387

    [PubMed - indexed for MEDLINE]

    PMCID:

    PMC4304769

    [Available on 2015-08-01]

    ncbi.nlm.nih.gov/pubmed/248...

  • Thanks CatSlave. Frustrating that whenever autoimmune disease / attack etc is mentioned in these articles and papers, thyroid is rarely if ever singled out <sigh>

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